(Q35221485)

7 August 2017

title

Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM. (English)

1 reference

Marisa L Martin-Fernandez

7 August 2017

author

Marisa L Martin-Fernandez

16

0 references

Daniel J Rolfe

Daniel J Rolfe

4

0 references

Simon Ameer-beg

Simon M Ameer-Beg

15

0 references

Borivoj Vojnovic

Borivoj Vojnovic

Peter Joseph Jacques Parker

11

0 references

Peter J Parker

12

0 references

Tony Ng

Tony Ng

17

0 references

Diane S. Lidke

14

Diane S Lidke

1 reference

7 August 2017

13

Keith A Lidke

1 reference

7 August 2017

Oana Coban

1

1 reference

7 August 2017

Laura C Zanetti-Dominguez

2

1 reference

7 August 2017

Daniel R Matthews

3

1 reference

7 August 2017

Gregory Weitsman

5

1 reference

7 August 2017

Paul R Barber

6

1 reference

7 August 2017

Jody Barbeau

7

1 reference

7 August 2017

Viviane Devauges

8

1 reference

7 August 2017

Florian Kampmeier

9

1 reference

7 August 2017

Martyn Winn

10

1 reference

7 August 2017

language of work or name

English

0 references

publication date

1 March 2015

1 reference

7 August 2017

1 reference

7 August 2017

volume

108

1 reference

7 August 2017

issue

5

1 reference

7 August 2017

page(s)

1013-1026

1 reference

describes a project that uses

7 August 2017

Bayes' theorem

1 reference

18 June 2022

https://europepmc.org/article/PMC/4375452

inferred from PubMed Central ID database lookup

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

13 July 2018

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13 July 2018

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ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding

13 July 2018

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13 July 2018

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How Förster resonance energy transfer imaging improves the understanding of protein interaction networks in cancer biology

13 July 2018

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13 July 2018

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Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

13 July 2018

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Kinase-mediated quasi-dimers of EGFR

13 July 2018

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13 July 2018

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Fluorescence lifetime cross correlation spectroscopy resolves EGFR and antagonist interaction in live cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Rapid optical imaging of EGF receptor expression with a single-chain antibody SNAP-tag fusion protein

13 July 2018

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AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Reversible dimerization of EGFR revealed by single-molecule fluorescence imaging using quantum dots

13 July 2018

1 reference

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

13 July 2018

1 reference

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Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

13 July 2018

1 reference

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An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment

13 July 2018

1 reference

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The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

13 July 2018

1 reference

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Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization

13 July 2018

1 reference

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Structure-based view of epidermal growth factor receptor regulation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Quantifying the effects of co-expressing EGFR and HER2 on HER activation and trafficking

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Structure and clinical relevance of the epidermal growth factor receptor in human cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Single-molecule imaging and fluorescence lifetime imaging microscopy show different structures for high- and low-affinity epidermal growth factor receptors in A431 cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

ErbB receptors: from oncogenes to targeted cancer therapies

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Counting of six pRNAs of phi29 DNA-packaging motor with customized single-molecule dual-view system

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Single-molecule analysis of epidermal growth factor binding on the surface of living cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

EGF-ERBB signalling: towards the systems level

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

A comprehensive pathway map of epidermal growth factor receptor signaling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Conformational heterogeneity in RNA polymerase observed by single-pair FRET microscopy.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Using computational modeling to drive the development of targeted therapeutics

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Active and inactive conformations of the epidermal growth factor receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

EGF signalling amplification induced by dynamic clustering of EGFR.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Imaging phosphorylation dynamics of the epidermal growth factor receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Single-molecule imaging of EGFR signalling on the surface of living cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Imaging protein kinase Calpha activation in cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Single-molecule enzymatic dynamics

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Two EGF molecules contribute additively to stabilization of the EGFR dimer

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Optimizing properties of antireceptor antibodies using kinetic computational models and experiments

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4375452

Single-molecule diffusion study of activated EGFR implicates its endocytic pathway

26 September 2018

1 reference

12 December 2020

Transient GPI-anchored protein homodimers are units for raft organization and function

1 reference

12 December 2020

Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer

1 reference

12 December 2020

Epidermal growth factor

1 reference

12 December 2020

10.1016/J.BPJ.2015.01.005

Identifiers

DOI

1 reference

7 August 2017

1 reference

7 August 2017

1 reference