(Q36511804)

English

HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling

scientific article published on October 2012

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling (English)

1 reference

Europe PubMed Central

14 August 2017

author name string

Z Hartman

1

1 reference

Europe PubMed Central

14 August 2017

H Zhao

2

1 reference

Europe PubMed Central

14 August 2017

Y M Agazie

3

1 reference

Europe PubMed Central

14 August 2017

language of work or name

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publication date

1 October 2012

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

32

1 reference

Europe PubMed Central

14 August 2017

35

1 reference

Europe PubMed Central

14 August 2017

4169-4180

1 reference

Europe PubMed Central

14 August 2017

https://scigraph.springernature.com/pub.10.1038/onc.2012.418

0 references

Efficacy and tolerability of lapatinib in the management of breast cancer

1 reference

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1 reference

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Activation of Ras requires the ERM-dependent link of actin to the plasma membrane

1 reference

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The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR.

1 reference

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Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

1 reference

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Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system

1 reference

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Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

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Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor

1 reference

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p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling

1 reference

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30 September 2017

Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network.

1 reference

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A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy

1 reference

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Dual silencing of type 1 insulin-like growth factor and epidermal growth factor receptors to induce apoptosis of nasopharyngeal cancer cells

1 reference

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Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs

1 reference

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30 September 2017

The ErbB2 signaling network as a target for breast cancer therapy

1 reference

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

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Phosphotyrosine interactome of the ErbB-receptor kinase family

1 reference

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30 September 2017

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor

1 reference

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30 September 2017

HER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review

1 reference

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30 September 2017

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

HER2-Mediated Effects on EGFR Endosomal Sorting: Analysis of Biophysical Mechanisms

1 reference

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

1 reference

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30 September 2017

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

1 reference

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30 September 2017

Grb2 regulates internalization of EGF receptors through clathrin-coated pits

1 reference

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EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

1 reference

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30 September 2017

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

1 reference

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Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

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30 September 2017

Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers

1 reference

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Increased mitogenicity of an alphabeta heterodimeric PDGF receptor complex correlates with lack of RasGAP binding

1 reference

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ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

1 reference

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

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Structural and functional diversity in the FGF receptor multigene family

1 reference

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30 September 2017

Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

Structural diversity and binding of FGF receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

30 September 2017

SH2 and SH3 domains: from structure to function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

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Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

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Differential regulation of rasGAP and neurofibromatosis gene product activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

28 June 2018

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 September 2018

Structural and Functional Diversity in the FGf Receptor Multigene Family

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.418

21 January 2018

Endocytosis and intracellular trafficking of ErbBs

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.418

21 January 2018

Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538112

21 October 2018

Interaction of Shc with Grb2 regulates the Grb2 association with mSOS

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.418

31 March 2020

Identifiers

10.1038/ONC.2012.418

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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