(Q35264010)

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Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde

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14 February 2020

Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde (English)

1 reference

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14 February 2020

author name string

Noriko Takuwa

1

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14 February 2020

Wa Du

2

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14 February 2020

Erika Kaneko

3

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14 February 2020

Yasuo Okamoto

4

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14 February 2020

Kazuaki Yoshioka

5

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14 February 2020

Yoh Takuwa

6

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14 February 2020

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16 February 2011

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14 February 2020

American Journal of Cancer Research

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14 February 2020

1

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14 February 2020

460-481

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14 February 2020

4

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14 February 2020

Roles of sphingosine-1-phosphate signaling in angiogenesis

1 reference

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27 July 2018

A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors

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27 July 2018

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration

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27 July 2018

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature

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27 July 2018

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

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27 July 2018

Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

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27 July 2018

FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.

1 reference

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27 July 2018

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.

1 reference

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27 July 2018

Extracellular and intracellular actions of sphingosine-1-phosphate

1 reference

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27 July 2018

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

1 reference

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27 July 2018

Sphingosine 1-phosphate and cancer

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27 July 2018

Endothelial functions of sphingosine-1-phosphate

1 reference

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27 July 2018

S1P1 receptor directs the release of immature B cells from bone marrow into blood.

1 reference

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27 July 2018

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

1 reference

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27 July 2018

p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment

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27 July 2018

Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver

1 reference

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27 July 2018

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

1 reference

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27 July 2018

HIF-1: upstream and downstream of cancer metabolism

1 reference

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27 July 2018

Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function

1 reference

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27 July 2018

Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes

1 reference

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27 July 2018

When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.

1 reference

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27 July 2018

Regulation of vascular physiology and pathology by the S1P2 receptor subtype.

1 reference

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27 July 2018

Sphingosine kinase and sphingosine 1-phosphate in cardioprotection

1 reference

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27 July 2018

Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation.

1 reference

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27 July 2018

Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection

1 reference

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27 July 2018

Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61

1 reference

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27 July 2018

S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor

1 reference

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27 July 2018

Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions

1 reference

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27 July 2018

The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors

1 reference

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27 July 2018

The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.

1 reference

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27 July 2018

Bioactive sphingolipids: metabolism and function

1 reference

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27 July 2018

Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival

1 reference

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27 July 2018

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

1 reference

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27 July 2018

Role for sphingosine kinase 1 in colon carcinogenesis.

1 reference

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27 July 2018

The alliance of sphingosine-1-phosphate and its receptors in immunity

1 reference

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27 July 2018

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

1 reference

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27 July 2018

Sphingosine-1-phosphate regulation of mammalian development.

1 reference

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27 July 2018

The vascular S1P gradient-cellular sources and biological significance

1 reference

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27 July 2018

The role of myeloid cells in the promotion of tumour angiogenesis

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27 July 2018

v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins

1 reference

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27 July 2018

Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells

1 reference

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27 July 2018

Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling

1 reference

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27 July 2018

Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

1 reference

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27 July 2018

Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

1 reference

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27 July 2018

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

1 reference

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27 July 2018

The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice

1 reference

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27 July 2018

S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

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27 July 2018

RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis

1 reference

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27 July 2018

S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells

1 reference

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27 July 2018

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

1 reference

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27 July 2018

A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death

1 reference

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27 July 2018

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation

1 reference

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27 July 2018

Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells

1 reference

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27 July 2018

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

1 reference

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27 July 2018

High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation

1 reference

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27 July 2018

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

1 reference

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27 July 2018

Sphingosine kinase 1 is up-regulated in colon carcinogenesis

1 reference

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27 July 2018

Essential role for sphingosine kinases in neural and vascular development

1 reference

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27 July 2018

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

1 reference

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27 July 2018

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

1 reference

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27 July 2018

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

1 reference

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27 July 2018

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration

1 reference

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27 July 2018

Regulation of PTEN by Rho small GTPases

1 reference

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27 July 2018

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

1 reference

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27 July 2018

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

1 reference

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27 July 2018

Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.

1 reference

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27 July 2018

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

1 reference

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27 July 2018

Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference

1 reference

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27 July 2018

Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization

1 reference

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27 July 2018

Cell surface receptors in lysophospholipid signaling

1 reference

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27 July 2018

Structural and functional characteristics of S1P receptors.

1 reference

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27 July 2018

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

1 reference

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27 July 2018

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

1 reference

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27 July 2018

Cell migration: Rho GTPases lead the way

1 reference

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27 July 2018

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

1 reference

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27 July 2018

Discovery and evaluation of inhibitors of human sphingosine kinase

1 reference

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27 July 2018

Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

1 reference

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27 July 2018

Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform

1 reference

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27 July 2018

Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2

1 reference

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27 July 2018

Lysophospholipid regulation of mononuclear phagocytes

1 reference

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27 July 2018

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

1 reference

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27 July 2018

Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors.

1 reference

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27 July 2018

Physiological and pathophysiological roles of lysophosphatidic acids produced by secretory lysophospholipase D in body fluids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

An oncogenic role of sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Molecular cloning and functional characterization of murine sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Ceramide: an intracellular signal for apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Stimulation of mitogenesis and glucose transport by 1-monooleoylglycerol in Swiss 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Intracellular calcium release mediated by sphingosine derivatives generated in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Role of Ca2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Stimulation of calcium mobilization but not proliferation by bombesin and tachykinin neuropeptides in human small cell lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Lysophosphatidic acid induces inward currents in Xenopus laevis oocytes; evidence for an extracellular site of action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

27 July 2018

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

An update on sphingosine-1-phosphate and other sphingolipid mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

FTY720 inhibits tumor growth and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Calcium, calmodulin and cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

26 September 2018

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3186046

15 November 2018

The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of intact inositol-1,4,5-trisphosphate-sensitive Ca2+ stores in cell cycle progression at the G1/S boundary in serum-stimulated human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of vasopressor phospholipid in crude soybean lecithin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregant rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21984966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984966%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21984966%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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