(Q35343147)

7 August 2017

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A genome-wide association study of aging (English)

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genome-wide association study

7 August 2017

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author

Sudha Seshadri

36

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38

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46

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50

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51

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17

Eric Boerwinkle

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Emelia J. Benjamin

14

Emelia J Benjamin

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Mika Kivimäki

47

Mika Kivimaki

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Stefan Walter

Stefan Walter

1

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David Karasik

David Karasik

24

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Joanne M Murabito

Joanne M Murabito

49

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Kathryn L. Lunetta

Kathryn L Lunetta

7

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Douglas P. Kiel

Douglas P Kiel

25

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Uwe Völker

Uwe Völker

11

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Jerome I Rotter

35

Jerome I Rotter

1 reference

7 August 2017

3

Ellen W Demerath

1 reference

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21

Tamara B Harris

1 reference

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Cornelia M. van Duijn

39

Cornelia van Duijn

1 reference

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45

Luigi Ferrucci

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44

David A Bennett

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28

Lenore J Launer

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6

Meena Kumari

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34

Eric M Reiman

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48

Yongmei Liu

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23

Albert Hofman

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42

Stefania Bandinelli

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33

Bruce M Psaty

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52

Nora Franceschini

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31

Johan Mackenbach

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30

Pamela L Lutsey

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19

Philip L De Jager

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41

M Carola Zillikens

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9

Toshiko Tanaka

1 reference

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8

Yuri Milaneschi

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10

Gregory J Tranah

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4

Melissa E Garcia

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29

Kurt K Lohman

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37

Michelle D Shardell

1 reference

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15

Reiner Biffar

1 reference

7 August 2017

40

Jeremy Walston

1 reference

7 August 2017

32

Kristin Marciante

1 reference

7 August 2017

Sebastian E Baumeister

43

Sebastian E Baumeister

1 reference

7 August 2017

13

Alice Arnold

1 reference

7 August 2017

16

Aron S Buchman

1 reference

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20

Denis A Evans

1 reference

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Gil Atzmon

2

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Robert C Kaplan

5

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Lei Yu

12

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7 August 2017

David Couper

18

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Wolfgang Hoffmann

22

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Thomas Kocher

26

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Maris Kuningas

27

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22 July 2011

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Neurobiology of Aging

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32

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2109.e15-28

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7 August 2017

11

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describes a project that uses

7 August 2017

genome-wide association study

1 reference

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

inferred from title

cites work

1 reference

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Biodemography of human ageing

27 July 2018

1 reference

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Neural mechanisms of ageing and cognitive decline

27 July 2018

1 reference

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27 July 2018

The genetics of ageing

1 reference

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Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts

27 July 2018

1 reference

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Next-generation sequencing in aging research: emerging applications, problems, pitfalls and possible solutions

27 July 2018

1 reference

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Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.

27 July 2018

1 reference

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27 July 2018

1 reference

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Wnt won the war: antagonistic role of Wnt over Shh controls dorso-ventral patterning of the vertebrate neural tube

27 July 2018

1 reference

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Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma

27 July 2018

1 reference

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Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

27 July 2018

1 reference

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Physiological functions of the HECT family of ubiquitin ligases

27 July 2018

1 reference

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LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons

27 July 2018

1 reference

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Association of FOXO3A variation with human longevity confirmed in German centenarians

27 July 2018

1 reference

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Practical aspects of imputation-driven meta-analysis of genome-wide association studies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Control of autophagy by oncogenes and tumor suppressor genes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

FOXO3A genotype is strongly associated with human longevity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Power for genetic association study of human longevity using the case-control design

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Medical sequencing at the extremes of human body mass

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

27 July 2018

The adversities of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

KCNQ4: a gene for age-related hearing impairment?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Principal components analysis corrects for stratification in genome-wide association studies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The quest for genetic determinants of human longevity: challenges and insights

27 July 2018

1 reference

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Cognitive aging as an extension of brain development: a model linking learning, brain plasticity, and neurodegeneration.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Clinical phenotype of families with longevity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genetics: influence of TOR kinase on lifespan in C. elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

PANTHER: a library of protein families and subfamilies indexed by function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Emerging trends in the search for genetic variants predisposing to human obesity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7)

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The allelic architecture of human disease genes: common disease-common variant... or not?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Are rare variants responsible for susceptibility to complex diseases?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The Rb/E2F pathway and cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The remarkable improvements in survival at older ages

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Longevity is moderately heritable in a sample of Danish twins born 1870-1880.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The myc oncogene: its role in transformation and differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Emerging roles of Wnts in the adult nervous system

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genome-wide association study identifies eight loci associated with blood pressure

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genome-wide association study of blood pressure and hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The Human Ageing Genomic Resources: online databases and tools for biogerontologists.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genes encoding longevity: from model organisms to humans

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Genetics of longevity and aging

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Differential expression of LMO4 protein in Alzheimer's disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Heritability and validity of healthy physical aging (wellness) in elderly male twins.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

New role of delta2-glutamate receptors in AMPA receptor trafficking and cerebellar function.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Morbidity profiles of centenarians: survivors, delayers, and escapers

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193030

Differences in the association between apolipoprotein E genotype and mortality across populations

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21782286

12 December 2020

inferred from PubMed ID database lookup

Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene"

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21782286

12 December 2020

inferred from PubMed ID database lookup

The genetics of aging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21782286

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.NEUROBIOLAGING.2011.05.026

1 reference

release_cm4alyj7kffwzowr4ployz5lbm

7 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cm4alyj7kffwzowr4ployz5lbm

24 November 2022

mapped directly with Wikidata item

PMCID

3193030

1 reference

7 August 2017

1 reference