(Q35350186)

7 August 2017

1 reference

title

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery? (English)

1 reference

7 August 2017

0 references

1 reference

Joshua B. Parsons

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

10 December 2024

Charles O. Rock

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

10 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21862391

10 December 2024

publication date

20 August 2011

1 reference

full work available at URL

7 August 2017

https://europepmc.org/articles/pmc3193581?pdf=render

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

https://europepmc.org/articles/PMC3193581

10 December 2024

file format

HyperText Markup Language

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

https://europepmc.org/articles/PMC3193581?pdf=render

10 December 2024

file format

Portable Document Format

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

https://doi.org/10.1016/j.mib.2011.07.029

10 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21862391

https://api.elsevier.com/content/article/PII:S1369527411001135?httpAccept=text/xml

10 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.MIB.2011.07.029

https://api.elsevier.com/content/article/PII:S1369527411001135?httpAccept=text/plain

10 December 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.MIB.2011.07.029

Current Opinion in Microbiology

10 December 2024

published in

1 reference

7 August 2017

volume

14

1 reference

7 August 2017

issue

5

1 reference

7 August 2017

page(s)

544-549

1 reference

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target

7 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Discovery and syntheses of "superbug challengers"-platensimycin and platencin

27 July 2018

1 reference

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Waves of resistance: Staphylococcus aureus in the antibiotic era.

27 July 2018

1 reference

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Membrane lipid homeostasis in bacteria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Lipid A modification systems in gram-negative bacteria

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Discovery of FabH/FabF inhibitors from natural products

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Discovery of a novel and potent class of FabI-directed antibacterial agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Molecular basis of triclosan activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Mechanism of triclosan inhibition of bacterial fatty acid synthesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

2-Acylglycerolphosphoethanolamine acyltransferase/acyl-acyl carrier protein synthetase is a membrane-associated acyl carrier protein binding protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Essentiality of FASII pathway for Staphylococcus aureus

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Vinaxanthone, a new FabI inhibitor from Penicillium sp.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Cephalochromin, a FabI-directed antibacterial of microbial origin.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

A high-throughput screening assay for the carboxyltransferase subunit of acetyl-CoA carboxylase.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

FapR, a Bacterial Transcription Factor Involved in Global Regulation of Membrane Lipid Biosynthesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3193581

Erratum: A triclosan-resistant bacterial enzyme

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21862391

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21862391

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21862391

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Brinster et al. reply

series ordinal

32

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.MIB.2011.07.029

10 December 2024

Identifiers

1 reference

7 August 2017

1 reference

7 August 2017

1 reference