(Q35378769)

8 August 2017

title

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors (English)

1 reference

8 August 2017

8

Sean F Brady

1 reference

8 August 2017

Jeremy G Owen

1

1 reference

8 August 2017

Zachary Charlop-Powers

2

1 reference

8 August 2017

Alexandra G Smith

3

1 reference

8 August 2017

Melinda A Ternei

4

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8 August 2017

Paula Y Calle

5

1 reference

8 August 2017

Boojala Vijay B Reddy

6

1 reference

8 August 2017

Daniel Montiel

7

1 reference

8 August 2017

language of work or name

English

0 references

publication date

23 March 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

8 August 2017

published in

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8 August 2017

volume

112

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8 August 2017

issue

14

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8 August 2017

page(s)

4221-4226

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A roadmap for natural product discovery based on large-scale genomics and metabolomics

8 August 2017

cites work

1 reference

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eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes

27 July 2018

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27 July 2018

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Insights into naturally minimised Streptomyces albus J1074 genome.

27 July 2018

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27 July 2018

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Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

27 July 2018

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Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.

27 July 2018

1 reference

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Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

27 July 2018

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phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data

27 July 2018

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Proteasome inhibitors: an expanding army attacking a unique target

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites

27 July 2018

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Ab initio gene identification in metagenomic sequences

27 July 2018

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FastTree: computing large minimum evolution trees with profiles instead of a distance matrix

27 July 2018

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BatchPrimer3: a high throughput web application for PCR and sequencing primer design

27 July 2018

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27 July 2018

The metagenomics of soil

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Comparative metagenomics of microbial communities

27 July 2018

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MUSCLE: a multiple sequence alignment method with reduced time and space complexity

27 July 2018

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The nitrilase superfamily: classification, structure and function

27 July 2018

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Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

Search and clustering orders of magnitude faster than BLAST

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

26 September 2018

1 reference

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Renaissance in antibacterial discovery from actinomycetes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394318

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1501124112

Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-β Signaling Modulators from Streptomyces sp

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1501124112

New PCR Primers for the Screening of NRPS and PKS-I Systems in Actinomycetes: Detection and Distribution of These Biosynthetic Gene Sequences in Major Taxonomic Groups

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1501124112

21 January 2018

Identifiers

DOI

10.1073/PNAS.1501124112

1 reference

8 August 2017

0 references

1 reference

8 August 2017

1 reference