(Q35423966)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Richard B Lock

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Carwyn Davies

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Linda A Hogarth

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Philipp A Dietrich

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Petra S Bachmann

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Andrew G Hall

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

7 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

37639-37650

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

12 February 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3199508

inferred from PubMed Central ID database lookup

cites work

DNA methylation of the first exon is tightly linked to transcriptional silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Enhanced antitumor therapy by inhibition of p21waf1 in human malignant mesothelioma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Diverse pathways mediate chemotherapy-induced cell death in acute lymphoblastic leukemia cell lines

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Apoptosis, p53, and tumor cell sensitivity to anticancer agents

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

mdm2 expression is induced by wild type p53 activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

WAF1, a potential mediator of p53 tumor suppression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Analysis of the mammalian gadd45 gene and its response to DNA damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Treatment of acute lymphoblastic leukemia

27 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

The p21(WAF1/CIP1) promoter is methylated in Rat-1 cells: stable restoration of p53-dependent p21(WAF1/CIP1) expression after transfection of a genomic clone containing the p21(WAF1/CIP1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Epigenetic modifications at the human growth hormone locus predict distinct roles for histone acetylation and methylation in placental gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

The role of p53 in chemosensitivity and radiosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

Methylation of the exon/intron region in the Ubi1 promoter complex correlates with transgene silencing in barley

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.272336

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3199508

Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia

26 September 2018

1 reference

12 December 2020

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells

1 reference

12 December 2020

p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis

1 reference

12 December 2020

Promoter hypermethylation of the cyclin-dependent kinase inhibitor (CDKI) gene p21WAF1/CIP1/SDI1 is rare in various lymphomas and carcinomas

1 reference

12 December 2020

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood

1 reference

12 December 2020

The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

1 reference

12 December 2020

Absence of WAF1 mutations in a variety of human malignancies

1 reference

12 December 2020

Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region

1 reference

12 December 2020

p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies

1 reference

12 December 2020

High levels of constitutive WAF1/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M111.272336

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21903579%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

21903579

1 reference