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mTOR and metabolic regulation of conventional and regulatory T cells.
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Europe PubMed Central
PMC publication ID
4398256
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
review article
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Europe PubMed Central
title
mTOR and metabolic regulation of conventional and regulatory T cells
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
author
Hu Zeng
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4
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Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
Hongbo Chi
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5
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Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
Nicole M Chapman
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2
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Nicole M Chapman
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Europe PubMed Central
PMC publication ID
4398256
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
author name string
Chaohong Liu
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1
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Europe PubMed Central
PMC publication ID
4398256
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
Peer W F Karmaus
series ordinal
3
1 reference
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Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
publication date
24 February 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
published in
Journal of Leukocyte Biology
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Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
volume
97
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Europe PubMed Central
PMC publication ID
4398256
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
page(s)
837-847
1 reference
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Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
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27 July 2018
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
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27 July 2018
Regulation of immune responses by mTOR.
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27 July 2018
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
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27 July 2018
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
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27 July 2018
CD8(+) T cells: foot soldiers of the immune system
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27 July 2018
Regulation of T-cell survival and mitochondrial homeostasis by TSC1
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27 July 2018
The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
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A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity
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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.
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Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques
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27 July 2018
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
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An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness.
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The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.
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Activation of a metabolic gene regulatory network downstream of mTOR complex 1
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27 July 2018
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
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27 July 2018
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
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27 July 2018
Glucose transporters in the 21st Century
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27 July 2018
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
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27 July 2018
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
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27 July 2018
Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation
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27 July 2018
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
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27 July 2018
mTOR regulates memory CD8 T-cell differentiation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
New insights into the regulation of T cells by gamma(c) family cytokines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Diacylglycerol kinases in immune cell function and self-tolerance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Diacylglycerol kinases: at the hub of cell signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
The therapeutic implications of intratumoral regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Reflections on CD8 T-cell activation and memory
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
27 July 2018
Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Regulatory T cell proliferative potential is impaired in human autoimmune disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
T cell receptor signalling networks: branched, diversified and bounded
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Regulatory T cells: recommendations to simplify the nomenclature.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Amino acids and mTORC1: from lysosomes to disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Differentiation of effector CD4 T cell populations (*)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Modulation of tryptophan catabolism by regulatory T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
IL-7 enhances the survival and maintains the size of naive T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4398256
retrieved
26 September 2018
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25714803
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inhibitory effect of tumor cell-derived lactic acid on human T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25714803
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25714803
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A key role of leptin in the control of regulatory T cell proliferation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25714803
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1189/JLB.2RI0814-408R
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PMC publication ID
4398256
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PubMed publication ID
25714803
1 reference
stated in
Europe PubMed Central
PMC publication ID
4398256
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25714803%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
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