(Q35434947)

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A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

Mohammad M Haque

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Claire Kenney

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Dennis J Stuehr

4

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11 February 2020

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publication date

15 September 2011

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Europe PubMed Central

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11 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

278

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

21

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

4055-4069

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Conformation-dependent hydride transfer in neuronal nitric oxide synthase reductase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

NO synthase: structures and mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Effects of interdomain tether length and flexibility on the kinetics of intramolecular electron transfer in human sulfite oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Flavin-containing heme enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

The journey from NADPH-cytochrome P450 oxidoreductase to nitric oxide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Update on mechanism and catalytic regulation in the NO synthases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Electron transfer by diflavin reductases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Electron transfer in human cytochrome P450 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Nitric oxide synthases: domain structure and alignment in enzyme function and control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Large scale domain movement in cytochrome bc(1): a new device for electron transfer in proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Investigation of the rate limiting step for electron transfer from NADPH:cytochrome P450 reductase to cytochrome b5: a laser flash-photolysis study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

27 July 2018

Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Mechanisms for regulating electron transfer in multi-centre redox proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

An appraisal of multiple NADPH binding-site models proposed for cytochrome P450 reductase, NO synthase, and related diflavin reductase systems

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

GEPASI: a software package for modelling the dynamics, steady states and control of biochemical and other systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

26 September 2018

Structure and mechanism of the iron‐sulfur flavoprotein phthalate dioxygenase reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

26 September 2018

Electron transfer by neuronal nitric-oxide synthase is regulated by concerted interaction of calmodulin and two intrinsic regulatory elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200465

24 October 2018

Active-Site Dynamics and Large-Scale Domain Motions of Sulfite Oxidase: A Molecular Dynamics Study

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08310.X

21 January 2018

Nature of the Energy Landscape for Gated Electron Transfer in a Dynamic Redox Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21848659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the interface between the FMN and FAD domains in the control of redox potential and electronic transfer of NADPH-cytochrome P450 reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21848659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH-cytochrome P-450 oxidoreductase: flavin mononucleotide and flavin adenine dinucleotide domains evolved from different flavoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21848659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1742-4658.2011.08310.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21848659%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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