(Q46693396)

24 December 2017

title

C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase (English)

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24 December 2017

6

Elizabeth D Getzoff

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author name string

Mauro Tiso

1

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24 December 2017

David W Konas

2

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24 December 2017

Koustubh Panda

3

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24 December 2017

Elsa D Garcin

4

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24 December 2017

Manisha Sharma

5

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24 December 2017

Dennis J Stuehr

7

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24 December 2017

language of work or name

English

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publication date

8 September 2005

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24 December 2017

Journal of Biological Chemistry

published in

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24 December 2017

volume

280

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24 December 2017

page(s)

39208-39219

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24 December 2017

issue

47

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24 December 2017

Nitric oxide synthases: which, where, how, and why?

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Structure-function aspects in the nitric oxide synthases

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Nitric oxide synthases: structure, function and inhibition

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Structural basis for endothelial nitric oxide synthase binding to calmodulin

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Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer

21 January 2018

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Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer

21 January 2018

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Tetrahydrobiopterin radical enzymology

21 January 2018

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Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer

21 January 2018

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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

21 January 2018

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Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase

21 January 2018

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An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals

21 January 2018

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Atomic structure of ferredoxin-NADP+ reductase: prototype for a structurally novel flavoenzyme family

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Electron transfer by diflavin reductases.

21 January 2018

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Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

21 January 2018

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Switching pyridine nucleotide specificity in P450 BM3: mechanistic analysis of the W1046H and W1046A enzymes

21 January 2018

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Redox properties of the isolated flavin mononucleotide- and flavin adenine dinucleotide-binding domains of neuronal nitric oxide synthase

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Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

21 January 2018

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Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras

21 January 2018

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Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock

21 January 2018

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A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity

21 January 2018

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The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain

21 January 2018

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Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

21 January 2018

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Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity

21 January 2018

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An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase

21 January 2018

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Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity

21 January 2018

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Removal of a putative inhibitory element reduces the calcium-dependent calmodulin activation of neuronal nitric-oxide synthase

21 January 2018

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Control of electron transfer in nitric-oxide synthases. Swapping of autoinhibitory elements among nitric-oxide synthase isoforms

21 January 2018

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Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli.

21 January 2018

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Characterization of the roles of the 594-645 region in human endothelial nitric-oxide synthase in regulating calmodulin binding and electron transfer

21 January 2018

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Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains

21 January 2018

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Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.

21 January 2018

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A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis

21 January 2018

1 reference

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Purification and properties of nitric oxide synthases

21 January 2018

1 reference

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Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Potentiometric analysis of the flavin cofactors of neuronal nitric oxide synthase

21 January 2018

1 reference

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A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

A productive NADP+ binding mode of ferredoxin-NADP + reductase revealed by protein engineering and crystallographic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Towards a new interaction enzyme:coenzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Role of the C-terminal tyrosine of ferredoxin-nicotinamide adenine dinucleotide phosphate reductase in the electron transfer processes with its protein partners ferredoxin and flavodoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Update on mechanism and catalytic regulation in the NO synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

The C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507775200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507775200

1 reference

24 December 2017

PubMed ID

16150731

1 reference

24 December 2017