(Q35447223)

English

Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

multiple drug resistance

1 reference

based on heuristic

inferred from title

Matthew S. Varonka

object named as

Matthew S Varonka

3

0 references

Michael M. Gottesman

11

object named as

Michael M Gottesman

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

author name string

Matthew D Hall

1

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Kyle R Brimacombe

2

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Kristen M Pluchino

4

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Julie K Monda

5

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Jiayang Li

6

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Martin J Walsh

7

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Matthew B Boxer

8

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Timothy H Warren

9

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Europe PubMed Central

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8 August 2017

Henry M Fales

10

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8 August 2017

language of work or name

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publication date

1 August 2011

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Europe PubMed Central

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8 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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8 August 2017

54

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Europe PubMed Central

PubMed publication ID

8 August 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

5878-5889

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

4-(3-Iodo-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

4-(3-Fluoro-phen-yl)-1-(2-oxoindolin-3-yl-idene)thio-semicarbazide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes

1 reference

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27 July 2018

Identification of compounds selectively killing multidrug-resistant cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Is resistance useless? Multidrug resistance and collateral sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Characterization of gene rearrangements leading to activation of MDR-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Targeting multidrug resistance in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Dominant expression of multiple drug resistance after in vitro X-irradiation exposure in intraspecific Chinese hamster ovary hybrid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Development and characterization of a human sarcoma cell line, MES-SA, sensitive to multiple drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Inhibition of RNA-dependent DNA polymerase of Rous sarcoma virus by thiosemicarbazones and several cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Verapamil hypersensitivity of vincristine resistant Chinese hamster ovary cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

Pseudomonas exotoxin fusion proteins are potent immunogens for raising antibodies against P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

27 July 2018

A dual-fluorescence high-throughput cell line system for probing multidrug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

26 September 2018

Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

26 September 2018

Synthesis of some N4-substituted isatin-3-thiosemicarbazones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

26 September 2018

A phase I trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone in combination with gemcitabine for patients with advanced cancer

1 reference

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26 September 2018

Phase I and pharmacodynamic study of Triapine, a novel ribonucleotide reductase inhibitor, in patients with advanced leukemia

1 reference

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26 September 2018

Multidrug resistance in cancer: role of ATP-dependent transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201829

26 September 2018

Gain and loss of hypersensitivity to resistance modifiers in multidrug resistant Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21721528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Observations on the antileukemic activity of pyridine-2-carboxaldehyde thiosemicarbazone and thiocarbohydrazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/21721528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21721528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM2006047

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

ResearchGate publication ID

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