(Q35464851)

8 August 2017

title

The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation (English)

1 reference

8 August 2017

main subject

neoplastic stem cells

1 reference

10

Judy Lieberman

1 reference

8 August 2017

Man-Li Luo

1

1 reference

8 August 2017

Chang Gong

2

1 reference

8 August 2017

Chun-Hau Chen

3

1 reference

8 August 2017

Hai Hu

4

1 reference

8 August 2017

Pengyu Huang

5

1 reference

8 August 2017

Min Zheng

6

1 reference

8 August 2017

Yandan Yao

7

1 reference

8 August 2017

Shuo Wei

8

1 reference

8 August 2017

Gerburg Wulf

9

1 reference

8 August 2017

Xiao Zhen Zhou

11

1 reference

8 August 2017

Erwei Song

12

1 reference

8 August 2017

Kun Ping Lu

13

1 reference

8 August 2017

publication date

26 March 2015

1 reference

8 August 2017

1 reference

8 August 2017

volume

11

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8 August 2017

issue

1

1 reference

8 August 2017

page(s)

111-124

1 reference

Prolyl isomerase Pin1 in cancer

8 August 2017

cites work

1 reference

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Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer

12 July 2018

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Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast.

12 July 2018

1 reference

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A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis

12 July 2018

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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma.

12 July 2018

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12 July 2018

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ERK1/2 MAP kinases: structure, function, and regulation

12 July 2018

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

12 July 2018

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Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

12 July 2018

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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

12 July 2018

1 reference

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Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The landscape of somatic copy-number alteration across human cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Rab GTPases as coordinators of vesicle traffic

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Supervised risk predictor of breast cancer based on intrinsic subtypes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Identification of tumor-initiating cells in a p53-null mouse model of breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

let-7 regulates self renewal and tumorigenicity of breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Hyperactive Ras in developmental disorders and cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Purification and unique properties of mammary epithelial stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Wnt signalling in stem cells and cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

A novel mechanism for mitogen-activated protein kinase localization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Prospective identification of tumorigenic breast cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Oncogenic kinase signalling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

A conserved docking motif in MAP kinases common to substrates, activators and regulators

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

ERGIC-53 and traffic in the secretory pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Rab2 is essential for the maturation of pre-Golgi intermediates

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

A human peptidyl-prolyl isomerase essential for regulation of mitosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Ras signalling on the endoplasmic reticulum and the Golgi

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

Targeting breast cancer stem cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4401741

The humoral immune system has a key prognostic impact in node-negative breast cancer

24 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25818297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25818297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Graphical representation of a generalized linear model-based statistical test estimating the fit of the single-hit Poisson model to limiting dilution assays

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25818297

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2015.03.002

1 reference

8 August 2017

1 reference

8 August 2017

1 reference