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Opposing effects of target overexpression reveal drug mechanisms
scientific article published on July 2014
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scholarly article
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Europe PubMed Central
PMC publication ID
4408919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
title
Opposing effects of target overexpression reveal drug mechanisms
(English)
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Europe PubMed Central
PMC publication ID
4408919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
main subject
overexpression
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inferred from title
author
Adam C. Palmer
series ordinal
1
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Europe PubMed Central
PMC publication ID
4408919
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
Roy Kishony
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2
object named as
Roy Kishony
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Europe PubMed Central
PMC publication ID
4408919
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language of work or name
English
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publication date
1 July 2014
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4408919
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21 March 2020
published in
Nature Communications
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21 March 2020
volume
5
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Europe PubMed Central
PMC publication ID
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21 March 2020
page(s)
4296
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Europe PubMed Central
PMC publication ID
4408919
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21 March 2020
cites work
Evaluating the fitness cost of protein expression in Saccharomyces cerevisiae.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Platforms for antibiotic discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Sub-inhibitory cefsulodin sensitization of E. coli to β-lactams is mediated by PBP1b inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
High-frequency transposition for determining antibacterial mode of action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Gene amplification and insecticide resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Depletion of antibiotic targets has widely varying effects on growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Beta-lactam antibiotics: from antibiosis to resistance and bacteriology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Gene amplification confers glyphosate resistance in Amaranthus palmeri.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Recent advances and method development for drug target identification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
A stochastic single-molecule event triggers phenotype switching of a bacterial cell
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Overproduction of penicillin-binding protein 2 and its inactive variants causes morphological changes and lysis in Escherichia coli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Drugs, their targets and the nature and number of drug targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Engineered gene over-expression as a method of drug target identification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
A genome-wide overexpression screen in yeast for small-molecule target identification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
The biosynthesis of folic acid. II. Inhibition by sulfonamides.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Environmental stresses can alleviate the average deleterious effect of mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Mechanism of triclosan inhibition of bacterial fatty acid synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Genomic profiling of drug sensitivities via induced haploinsufficiency.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
DNA gyrase, topoisomerase IV, and the 4-quinolones
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Gene amplification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Targeted selection of recombinant clones through gene dosage effects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Folate antagonists as antibacterial and antiprotozoal agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Massive overproduction of dihydrofolate reductase in bacteria as a response to the use of trimethoprim
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Mechanism of bactericidal action of aminoglycosides.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Gene amplification and drug resistance in cultured murine cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Energy coupling in DNA gyrase and the mechanism of action of novobiocin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
12 July 2018
Cost-benefit tradeoffs in engineered lac operons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
Triclosan resistance in clinical isolates of Acinetobacter baumannii.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
Genomic approaches to antibacterial discovery.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
Sulfonamide resistance: mechanisms and trends.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
Lysis of Escherichia coli by beta-lactam antibiotics: deletion analysis of the role of penicillin-binding proteins 1A and 1B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4408919
retrieved
26 September 2018
INCREASED SYNTHESIS OF p-AMINOBENZOIC ACID ASSOCIATED WITH THE DEVELOPMENT OF SULFONAMIDE RESISTANCE IN STAPHYLOCOCCUS AUREUS
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24980690
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sulfonamide structure-activity relationships in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24980690
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A mecillinam-sensitive peptidoglycan crosslinking reaction in
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24980690
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NCOMMS5296
1 reference
stated in
Europe PubMed Central
PMC publication ID
4408919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
ADS bibcode
2014NatCo...5.4296P
0 references
PMC publication ID
4408919
1 reference
stated in
Europe PubMed Central
PMC publication ID
4408919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
PubMed publication ID
24980690
1 reference
stated in
Europe PubMed Central
PMC publication ID
4408919
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24980690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 March 2020
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