(Q34571023)

3 August 2017

1 reference

title

Drugs, their targets and the nature and number of drug targets (English)

1 reference

3 August 2017

Peter Imming

1

1 reference

PubMed ID

17016423

3 August 2017

Christian Sinning

series ordinal

2

1 reference

PubMed ID

17016423

3 August 2017

Achim Meyer

series ordinal

3

1 reference

3 August 2017

1 October 2006

1 reference

Nature Reviews Drug Discovery

3 August 2017

1 reference

3 August 2017

5

1 reference

3 August 2017

821-834

1 reference

3 August 2017

10

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2132

3 August 2017

0 references

cites work

Trends in virtual combinatorial library design

1 reference

Library design practices for success in lead generation with small molecule libraries

21 January 2018

1 reference

Molecular, biochemical, and cellular pharmacology of pemetrexed

21 January 2018

1 reference

Progress towards the discovery of xanthine oxidase inhibitors.

21 January 2018

1 reference

L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus

21 January 2018

1 reference

The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory cytokines

21 January 2018

1 reference

Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature

21 January 2018

1 reference

21 January 2018

Decarboxylase inhibitors

1 reference

Etoposide: discovery and medicinal chemistry

21 January 2018

1 reference

Mechanism of action of fibrates on lipid and lipoprotein metabolism

21 January 2018

1 reference

Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4

21 January 2018

1 reference

The role of innovation in drug development

21 January 2018

1 reference

31 March 2020

1 reference

Knockouts model the 100 best-selling drugs--will they model the next 100?

31 March 2020

1 reference

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

31 March 2020

1 reference

How receptor mosaics decode transmitter signals. Possible relevance of cooperativity.

31 March 2020

1 reference

Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats

31 March 2020

1 reference

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

31 March 2020

1 reference

Medicine. What are the right targets for psychopharmacology?

31 March 2020

1 reference

Illuminating drug discovery with biological pathways

31 March 2020

1 reference

Relibase: design and development of a database for comprehensive analysis of protein-ligand interactions

31 March 2020

1 reference

Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors

31 March 2020

1 reference

Biochemical mechanisms of drug action: what does it take for success?

31 March 2020

1 reference

Mechanistic basis of enzyme-targeted drugs

31 March 2020

1 reference

Probing conformational changes in neurotransmitter transporters: a structural context

31 March 2020

1 reference

A functional-phylogenetic system for the classification of transport proteins

31 March 2020

1 reference

Cancer chemoprevention drug targets

31 March 2020

1 reference

Designed multiple ligands. An emerging drug discovery paradigm

31 March 2020

1 reference

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

31 March 2020

1 reference

Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials

31 March 2020

1 reference

Multicomponent therapeutics for networked systems

31 March 2020

1 reference

Antiarrhythmic drugs: past, present and future

31 March 2020

1 reference

Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

31 March 2020

1 reference

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

31 March 2020

1 reference

Relationships between structure and vascular activity in a series of benzylisoquinolines

31 March 2020

1 reference

Drug discovery: playing dirty

31 March 2020

1 reference

The structures of prostaglandin endoperoxide H synthases-1 and -2.

31 March 2020

1 reference

The enzymology of prostaglandin endoperoxide H synthases-1 and -2.

31 March 2020

1 reference

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

31 March 2020

1 reference

The challenge of regulating anticoagulant drugs: focus on warfarin

31 March 2020

1 reference

Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer

31 March 2020

1 reference

History of the development of azole derivatives

31 March 2020

1 reference

The role of aminosalicylates at the beginning of the new millennium in the treatment of chronic inflammatory bowel disease

31 March 2020

1 reference

The role of leukotriene inhibitors in patients with paranasal sinus disease

31 March 2020

1 reference

Mycophenolate mofetil and its mechanisms of action

31 March 2020

1 reference

Statins: mechanism of action and effects.

31 March 2020

1 reference

Targeting DHFR in parasitic protozoa

31 March 2020

1 reference

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

31 March 2020

1 reference

The mechanism of action of terbinafine

31 March 2020

1 reference

Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.

31 March 2020

1 reference

Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisers

31 March 2020

1 reference

31 March 2020

1 reference

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

31 March 2020

1 reference

Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase

31 March 2020

1 reference

Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).

31 March 2020

1 reference

Non-nucleoside reverse transcriptase inhibitors--an overview

31 March 2020

1 reference

Histone deacetylase is a target of valproic acid-mediated cellular differentiation

31 March 2020

1 reference

Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate

31 March 2020

1 reference

Structure and function of the Mur enzymes: development of novel inhibitors

31 March 2020

1 reference

Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

31 March 2020

1 reference

The proteasome: a suitable antineoplastic target

31 March 2020

1 reference

Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor

31 March 2020

1 reference

Organophosphate pesticides: biochemistry and clinical toxicology

31 March 2020

1 reference

Caffeine as a psychomotor stimulant: mechanism of action.

31 March 2020

1 reference

Inhibitory mechanism of papaverine on carbachol-induced contraction in bovine trachea

31 March 2020

1 reference

Molecular biology and pharmacology of PDE-5-inhibitor therapy for erectile dysfunction.

31 March 2020

1 reference

Carbamazepine is an inhibitor of histone deacetylases

31 March 2020

1 reference

New approaches to influenza chemotherapy. Neuraminidase inhibitors

31 March 2020

1 reference

31 March 2020

1 reference

Antiretrovirals, part 1: overview, history, and focus on protease inhibitors

31 March 2020

1 reference

Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

31 March 2020

1 reference

The beta-lactamase cycle: a tale of selective pressure and bacterial ingenuity

31 March 2020

1 reference

Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety

31 March 2020

1 reference

Heparins and heparinoids: occurrence, structure and mechanism of antithrombotic and hemorrhagic activities

31 March 2020

1 reference

Diamine oxidase: an overview of historical, biochemical and functional aspects

31 March 2020

1 reference

The blood coagulation system as a molecular machine

31 March 2020

1 reference

Rationales Design von Hemmern: Vom Teprotid zum Captopril

31 March 2020

1 reference

Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology.

31 March 2020

1 reference

Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases

31 March 2020

1 reference

Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism

31 March 2020

1 reference

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

31 March 2020

1 reference

The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity

31 March 2020

1 reference

Carbonic anhydrase inhibitors

31 March 2020

1 reference

Molecular mechanisms of polyamine analogs in cancer cells

31 March 2020

1 reference

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

31 March 2020

1 reference

Nitrates and NO release: contemporary aspects in biological and medicinal chemistry.

31 March 2020

1 reference

After 130 years, the molecular mechanism of action of nitroglycerin is revealed

31 March 2020

1 reference

Cyclic GMP as the mediator of molsidomine-induced vasodilatation.

31 March 2020

1 reference

A Side Reaction of Alanine Racemase: Transamination of Cycloserine,

31 March 2020

1 reference

Fluoroquinolones: action and resistance

31 March 2020

1 reference

31 March 2020

1 reference

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

31 March 2020

1 reference

5-Fluorouracil: mechanisms of action and clinical strategies

31 March 2020

1 reference

Thermodynamic study of the interaction of methotrexate, its metabolites, and new antifolates with thymidylate synthase: influence of FdUMP

31 March 2020

1 reference

Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni

31 March 2020

1 reference

Sirolimus: its discovery, biological properties, and mechanism of action

31 March 2020

1 reference

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents

31 March 2020

1 reference

Echinocandin antifungal drugs

31 March 2020

1 reference

31 March 2020

1 reference

Pegaspargase: a review of clinical studies

31 March 2020

1 reference

Botulinum toxin: mechanisms of action

31 March 2020

1 reference

Mechanisms of action of antiepileptic drugs.

31 March 2020

1 reference

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

31 March 2020

1 reference

Modes of action of anthelmintic drugs

31 March 2020

1 reference

31 March 2020

1 reference

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

31 March 2020

1 reference

Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate

31 March 2020

1 reference

[Mechanisms of action of ketamine]

31 March 2020

1 reference

Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice

31 March 2020

1 reference

Therapeutic opportunities from muscarinic receptor research

31 March 2020

1 reference

Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo

31 March 2020

1 reference

Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs

31 March 2020

1 reference

Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors

31 March 2020

1 reference

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications

31 March 2020

1 reference

Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.

31 March 2020

1 reference

Angiotensin II type 1 receptor blockers

31 March 2020

1 reference

Is the calcium receptor a molecular target for the actions of strontium on bone?

31 March 2020

1 reference

Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

31 March 2020

1 reference

Structure and function of dopamine receptors

31 March 2020

1 reference

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

31 March 2020

1 reference

Molecular determinants of glucagon receptor signaling

31 March 2020

1 reference

31 March 2020

1 reference

Advances in H1-antihistamines

31 March 2020

1 reference

Molecular biology of opioid analgesia

31 March 2020

1 reference

G protein-coupled receptor structural motifs: relevance to the opioid receptors

31 March 2020

1 reference

Potential of substance P antagonists as antiemetics

31 March 2020

1 reference

Prostanoid receptors: structures, properties, and functions

31 March 2020

2 references

31 March 2020

7 January 2021

Update on the mechanism of action of bimatoprost: a review and discussion of new evidence

1 reference

P2Y12, a new platelet ADP receptor, target of clopidogrel

31 March 2020

1 reference

Molecular Basis of Buspirone's Anxiolytic Action

31 March 2020

1 reference

Where do triptans act in the treatment of migraine?

31 March 2020

1 reference

Serotonin receptors: their key role in drugs to treat schizophrenia

31 March 2020

1 reference

Basic and clinical pharmacology of new motility promoting agents

31 March 2020

1 reference

Molecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor family.

31 March 2020

1 reference

Vasopressin and terlipressin: pharmacology and its clinical relevance

31 March 2020

1 reference

Discovery and mechanism of action of pegvisomant

31 March 2020

1 reference

Clinical applications of colony-stimulating factors: a historical perspective.

31 March 2020

1 reference

Anakinra: an inhibitor of IL-1 for the treatment of rheumatoid arthritis

31 March 2020

1 reference

Aldesleukin in advanced renal cell carcinoma

31 March 2020

1 reference

Platelet GPIIb-IIIa blockers

31 March 2020

1 reference

Modulation of insulin signalling by insulin sensitizers

31 March 2020

1 reference

Mineralocorticoid receptor binding, structure and function.

31 March 2020

1 reference

Crystallization of the human glucocorticoid receptor ligand binding domain: a step towards selective glucocorticoids.

31 March 2020

1 reference

Unfolding the action of progesterone receptors

31 March 2020

1 reference

Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology

31 March 2020

1 reference

Selective oestrogen receptor modulation: molecular pharmacology for the millennium

31 March 2020

1 reference

Molecular action of androgens

31 March 2020

1 reference

Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction.

31 March 2020

1 reference

Chemistry and structural biology of androgen receptor

31 March 2020

1 reference

The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research

31 March 2020

1 reference

Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands.

31 March 2020

1 reference

Vitamin D receptor as a drug discovery target

31 March 2020

1 reference

Retinoid receptors in transcriptional regulation

31 March 2020

1 reference

ACTH 1-24 inhibits proliferation of adrenocortical tumors in vivo

31 March 2020

1 reference

Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne

31 March 2020

1 reference

Mechanisms of actions of statins and fibrates

31 March 2020

1 reference

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

31 March 2020

1 reference

The molecular basis of thyroid hormone action

31 March 2020

1 reference

What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs?

31 March 2020

1 reference

Are Ca2+ channels targets of praziquantel action?

31 March 2020

1 reference

Mouse models to study L-type calcium channel function

31 March 2020

1 reference

1,4-Dihydropyridines as calcium channel ligands and privileged structures

31 March 2020

1 reference

Structural basis of drug binding to L Ca2+ channels

31 March 2020

1 reference

Lercanidipine: a novel lipophilic dihydropyridine calcium antagonist with long duration of action and high vascular selectivity.

31 March 2020

1 reference

31 March 2020

1 reference

Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2).

31 March 2020

1 reference

Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

31 March 2020

1 reference

Pharmacology of cardiac potassium channels.

31 March 2020

1 reference

New windows on the mechanism of action of K(ATP) channel openers

31 March 2020

1 reference

Comparative effects of K+ channel modulating agents on contractions of rat intestinal smooth muscle.

31 March 2020

1 reference

The mechanisms underlying the unique pharmacodynamics of nateglinide

31 March 2020

1 reference

Insulin secretagogues, sulfonylurea receptors and K(ATP) channels

31 March 2020

1 reference

Amiodarone: ionic and cellular mechanisms of action of the most promising class III agent

31 March 2020

1 reference

Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

31 March 2020

1 reference

31 March 2020

1 reference

Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in?

31 March 2020

1 reference

Effect of lamotrigine on the activities of monoamine oxidases A and B in vitro and on monoamine disposition in vivo

31 March 2020

1 reference

The interactions of phenytoin and its binding site in DI-S6 segment of Na+ channel voltage-gated peptide by NMR spectroscopy and molecular modeling study

31 March 2020

1 reference

The differentiation of propafenone from other class Ic agents, focusing on the effect on ventricular response rate attributable to its beta-blocking action

31 March 2020

1 reference

Molecular pharmacology of topiramate: managing seizures and preventing migraine

31 March 2020

1 reference

Lithium and valproic acid: parallels and contrasts in diverse signaling contexts

31 March 2020

1 reference

Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum.

31 March 2020

1 reference

The anandamide transport inhibitor AM404 activates vanilloid receptors.

31 March 2020

1 reference

The structural basis of ClC chloride channel function

31 March 2020

1 reference

Potent block of Cl- channels by antiallergic drugs

31 March 2020

1 reference

High-affinity ivermectin binding to recombinant subunits of the Haemonchus contortus glutamate-gated chloride channel

31 March 2020

1 reference

Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

31 March 2020

1 reference

Alternatively spliced isoform of apical Na(+)-K(+)-Cl(-) cotransporter gene encodes a furosemide-sensitive Na(+)-Cl(-)cotransporter

31 March 2020

1 reference

Identification of an amiloride binding domain within the alpha-subunit of the epithelial Na+ channel.

31 March 2020

1 reference

Artemisinins target the SERCA of Plasmodium falciparum

31 March 2020

1 reference

A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole

31 March 2020

1 reference

Interactions between cardiac glycosides and sodium/potassium-ATPase: three-dimensional structure-activity relationship models for ligand binding to the E2-Pi form of the enzyme versus activity inhibition.

31 March 2020

1 reference

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

31 March 2020

1 reference

Behavioral and biochemical investigations of bupropion metabolites

31 March 2020

1 reference

Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.

31 March 2020

1 reference

Molecular recognition of DNA by small molecules

31 March 2020

1 reference

DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards

31 March 2020

1 reference

32P-postlabeling analysis of binding of the cyclophosphamide metabolite, acrolein, to DNA.

31 March 2020

1 reference

Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations

31 March 2020

1 reference

Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent

31 March 2020

1 reference

Cisplatin: mode of cytotoxic action and molecular basis of resistance

31 March 2020

1 reference

The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes

31 March 2020

1 reference

Bleomycin: new perspectives on the mechanism of action

31 March 2020

1 reference

Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials

31 March 2020

1 reference

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

31 March 2020

1 reference

Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics

31 March 2020

1 reference

Novel aspects of natural and modified vinca alkaloids

31 March 2020

1 reference

The action and toxicity of taxanes

31 March 2020

1 reference

Update on colchicine and its mechanism of action

31 March 2020

1 reference

Drugs targeting the ribosome

31 March 2020

1 reference

Mapping of the second tetracycline binding site on the ribosomal small subunit of E.coli

31 March 2020

1 reference

Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications

31 March 2020

1 reference

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

31 March 2020

1 reference

Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of bevacizumab and cetuximab: an Acta Oncologica expert report

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Omalizumab: a novel therapy for allergic asthma

31 March 2020

1 reference

Yttrium-90-ibritumomab tiuxetan radioimmunotherapy: a new treatment approach for B-cell non-Hodgkin's lymphoma.

31 March 2020

1 reference

CD33-directed therapy with gemtuzumab ozogamicin in acute myeloid leukemia: progress in understanding cytotoxicity and potential mechanisms of drug resistance

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Daclizumab: a review of its use in the management of organ transplantation

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Abciximab (c7E3 Fab). A review of its pharmacology and therapeutic potential in ischaemic heart disease

31 March 2020

1 reference

31 March 2020

1 reference

Modulation of protein kinase C in antitumor treatment

31 March 2020

1 reference

7 January 2021

Neuromuscular blockers in surgery and intensive care, Part 1.

1 reference

7 January 2021

Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR

1 reference

7 January 2021

Granisetron: relating pharmacology to clinical efficacy

1 reference

7 January 2021

Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel

1 reference

7 January 2021

Identifiers

DOI

10.1038/NRD2132

1 reference

3 August 2017

1 reference

PubMed ID

17016423