(Q35551147)

8 August 2017

1 reference

title

Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents (English)

1 reference

8 August 2017

1

Brian J Nickoloff

1 reference

8 August 2017

Barbara A Osborne

2

1 reference

PubMed ID

14528285

8 August 2017

Lucio Miele

series ordinal

3

1 reference

PubMed ID

14528285

8 August 2017

language of work or name

English

0 references

publication date

1 September 2003

1 reference

8 August 2017

1 reference

8 August 2017

22

1 reference

8 August 2017

6598-6608

1 reference

8 August 2017

42

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206758

8 August 2017

0 references

cites work

Notch signaling in lymphocyte development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Notch signaling in mammary gland tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

The link between integration and expression of human papillomavirus type 16 genomes and cellular changes in the evolution of cervical intraepithelial neoplastic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Deciphering the role of Notch signaling in lymphopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Arbiter of differentiation and death: Notch signaling meets apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Sequential activation of Notch family receptors during mouse spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Numb is an endocytic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Functional diversity among Notch1, Notch2, and Notch3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Cutting edge: an essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Alterations in Notch signaling in neoplastic lesions of the human cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

An invitation to T and more: notch signaling in lymphopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch signalling controls pancreatic cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch1 inhibits neurite outgrowth in postmitotic primary neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch and Wingless signals collide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Chromosome 19 translocation, overexpression of Notch3, and human lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Ras pathway signals are required for notch-mediated oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Glycogen synthase kinase-3beta modulates notch signaling and stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Fringe benefits to carbohydrates.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

LIN-12/Notch signaling: lessons from worms and flies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Expression of notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Neoplastic transformation by Notch requires nuclear localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch pathway genes are expressed in mammalian ovarian follicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Evolutionary analysis of vertebrate Notch genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch signalling. A short cut to the nucleus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

A phylogenetic analysis of vertebrate and invertebrate Notch-related genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Human deltex is a conserved regulator of Notch signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Fringe is a glycosyltransferase that modifies Notch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Role of Notch-1 intracellular domain in activation of rheumatoid synoviocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch1 functions as a tumor suppressor in mouse skin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The notch pathway: modulation of cell fate decisions in hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Regulation of notch signaling by o-linked fucose.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch inhibition of E47 supports the existence of a novel signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Transcriptional control of T cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch and the immune system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Mastermind is a putative activator for Notch.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Requirement of Math1 for secretory cell lineage commitment in the mouse intestine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206758

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206758

1 reference

8 August 2017

1 reference

PubMed ID

14528285