(Q35562844)

English

Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling

scientific article published on 30 September 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

protein ubiquitination

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inferred from title

Jonathan T. Lei

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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Tuhina Mazumdar

2

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13 February 2020

Margarita Martinez-Moczygemba

3

1 reference

Europe PubMed Central

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13 February 2020

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30 September 2011

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13 February 2020

Journal of Biological Chemistry

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13 February 2020

286

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13 February 2020

46

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13 February 2020

40091-40103

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

The endocytic matrix

1 reference

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IL-5- and eosinophil-mediated inflammation: from discovery to therapy

1 reference

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12 July 2018

Endocytosis and signalling: intertwining molecular networks

1 reference

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12 July 2018

Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination.

1 reference

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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

1 reference

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12 July 2018

Biology of the eosinophil

1 reference

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12 July 2018

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

1 reference

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12 July 2018

Ubiquitin in trafficking: the network at work

1 reference

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12 July 2018

The many faces of the SOCS box.

1 reference

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12 July 2018

Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation

1 reference

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12 July 2018

Endocytosis and intracellular trafficking of ErbBs

1 reference

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12 July 2018

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

1 reference

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12 July 2018

Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Separate endocytic pathways regulate IL-5 receptor internalization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

1 reference

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12 July 2018

Regulation of GPCRs by endocytic membrane trafficking and its potential implications

1 reference

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12 July 2018

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Jaks and cytokine receptors--an intimate relationship

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Endocytosis conducts the cell signaling orchestra

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Janus kinase 2 enhances the stability of the mature growth hormone receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Polyubiquitin chains: polymeric protein signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220589

12 July 2018

Back to the future with ubiquitin

1 reference

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12 July 2018

Distinct monoubiquitin signals in receptor endocytosis

1 reference

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12 July 2018

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

1 reference

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12 July 2018

Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF

1 reference

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12 July 2018

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

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Signal dispersal and transduction through the endocytic pathway

1 reference

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The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

1 reference

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12 July 2018

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

1 reference

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12 July 2018

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

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12 July 2018

Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization

1 reference

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Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

1 reference

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Protein regulation by monoubiquitin

1 reference

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The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif

1 reference

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The signal transduction of the growth hormone receptor is regulated by the ubiquitin/proteasome system and continues after endocytosis

1 reference

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Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains

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Regulation of signal transduction by endocytosis

1 reference

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Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

1 reference

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1 reference

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JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation

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Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.

1 reference

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A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1 reference

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Eosinophils: biological properties and role in health and disease.

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A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization

1 reference

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21 January 2018

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process

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21 January 2018

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

1 reference

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Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling

1 reference

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PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Cytokine receptors and signal transduction

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/21965659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.273482

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

release_qkolx5q7zvefnbus4a4wc6kshy

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https://api.fatcat.wiki/v0/release/qkolx5q7zvefnbus4a4wc6kshy

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21965659%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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