(Q35574807)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Massimo Federico

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Flavio Rizzolio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Antonio Giordano

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Catherine E Symonds

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Luigi Bagella

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Daniele Fanale

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Antonio Russo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

publication date

4 August 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

9 February 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3224749

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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12 July 2018

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Methylation markers for CCNA1 and C13ORF18 are strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer in cervical scrapings

12 July 2018

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Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage

12 July 2018

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12 July 2018

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Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.

12 July 2018

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Distinct properties of cyclin-dependent kinase complexes containing cyclin A1 and cyclin A2.

12 July 2018

1 reference

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Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis

12 July 2018

1 reference

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Regulation of DNA repair throughout the cell cycle

12 July 2018

1 reference

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A quantitative analysis of kinase inhibitor selectivity

12 July 2018

1 reference

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DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA.

12 July 2018

1 reference

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Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Discovery and evaluation of dual CDK1 and CDK2 inhibitors

12 July 2018

1 reference

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affylmGUI: a graphical user interface for linear modeling of single channel microarray data

12 July 2018

1 reference

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

12 July 2018

1 reference

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

The cyclin A1-CDK2 complex regulates DNA double-strand break repair.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

E2F target genes: unraveling the biology

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Transcriptional signature of flavopiridol-induced tumor cell death.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

affy--analysis of Affymetrix GeneChip data at the probe level

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo

12 July 2018

1 reference

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Controlling the false discovery rate in behavior genetics research

12 July 2018

1 reference

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Cellular responses to DNA damage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Seliciclib in malignancies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Detection of alkylation damage in human lymphocyte DNA with the comet assay.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3224749

Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20684776

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-9-208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20684776%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

20684776

1 reference