(Q37088926)

18 August 2017

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title

Regulation of DNA repair throughout the cell cycle (English)

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18 August 2017

Dana Branzei

1

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Marco Foiani

object named as

Marco Foiani

series ordinal

2

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publication date

20 February 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

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18 August 2017

9

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18 August 2017

297-308

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18 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrm2351

18 August 2017

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Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast

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Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

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Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells

31 March 2020

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Cell cycle checkpoints: preventing an identity crisis

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

31 March 2020

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The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

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Chromatin modifications and their function

31 March 2020

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Chromatin modifications and DNA double-strand breaks: the current state of play

31 March 2020

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Chromatin challenges during DNA replication and repair

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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

31 March 2020

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Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides

31 March 2020

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Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases

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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

31 March 2020

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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

31 March 2020

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Recombination proteins in yeast

31 March 2020

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Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

31 March 2020

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Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

31 March 2020

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Yeast cell-type regulation of DNA repair

31 March 2020

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Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.

31 March 2020

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The multifaceted mismatch-repair system

31 March 2020

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The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae

31 March 2020

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Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

31 March 2020

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Interplay of replication checkpoints and repair proteins at stalled replication forks

31 March 2020

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Translesion synthesis: Y-family polymerases and the polymerase switch

31 March 2020

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

31 March 2020

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Mechanism of homologous recombination: mediators and helicases take on regulatory functions

31 March 2020

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Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

31 March 2020

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The Mre11 nuclease is not required for 5' to 3' resection at multiple HO-induced double-strand breaks

31 March 2020

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Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

31 March 2020

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Human CtIP promotes DNA end resection

31 March 2020

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New insights into the mechanism of homologous recombination in yeast

31 March 2020

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Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells

31 March 2020

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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

31 March 2020

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RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.

31 March 2020

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BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?

31 March 2020

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Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor

31 March 2020

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At the heart of the chromosome: SMC proteins in action

31 March 2020

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Cohesion between sister chromatids must be established during DNA replication

31 March 2020

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Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery

31 March 2020

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Postreplicative Formation of Cohesion Is Required for Repair and Induced by a Single DNA Break

31 March 2020

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DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).

31 March 2020

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Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.

31 March 2020

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Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.

31 March 2020

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DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain

31 March 2020

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Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

31 March 2020

1 reference

The human decatenation checkpoint.

31 March 2020

1 reference

ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase

31 March 2020

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DNA repair in differentiated cells: some new answers to old questions

31 March 2020

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Base excision repair and the central nervous system

31 March 2020

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DNA repair in neurons: so if they don't divide what's to repair?

31 March 2020

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DNA excision repair pathways

31 March 2020

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Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

31 March 2020

1 reference

Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells

31 March 2020

1 reference

The controlling role of ATM in homologous recombinational repair of DNA damage

31 March 2020

1 reference

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

31 March 2020

1 reference

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

31 March 2020

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RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells

31 March 2020

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Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress

31 March 2020

1 reference

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

31 March 2020

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The Fanconi anemia signalosome anchor

31 March 2020

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Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks

31 March 2020

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Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast

31 March 2020

1 reference

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

31 March 2020

1 reference

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

31 March 2020

1 reference

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

31 March 2020

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

31 March 2020

1 reference

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

31 March 2020

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Checkpoint activation regulates mutagenic translesion synthesis

31 March 2020

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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae

31 March 2020

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Gaps and forks in DNA replication: Rediscovering old models

31 March 2020

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Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

31 March 2020

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Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity

31 March 2020

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BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

31 March 2020

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Cdc2 Phosphorylation of Crb2 Is Required for Reestablishing Cell Cycle Progression after the Damage Checkpoint

31 March 2020

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Brca1 controls homology-directed DNA repair

31 March 2020

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BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

31 March 2020

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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

31 March 2020

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Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast

31 March 2020

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Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover

31 March 2020

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RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombination

31 March 2020

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

31 March 2020

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The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

31 March 2020

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

31 March 2020

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

31 March 2020

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

31 March 2020

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Regulation of mitotic exit by the RNF8 ubiquitin ligase

31 March 2020

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

31 March 2020

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Ubiquitin and SUMO systems in the regulation of mitotic checkpoints

31 March 2020

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Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

31 March 2020

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Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

31 March 2020

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

31 March 2020

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

31 March 2020

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

31 March 2020

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

31 March 2020

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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

31 March 2020

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

31 March 2020

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

31 March 2020

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

31 March 2020

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

31 March 2020

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

31 March 2020

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

31 March 2020

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Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

31 March 2020

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

31 March 2020

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Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

31 March 2020

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Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

31 March 2020

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

31 March 2020

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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

31 March 2020

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Control of Rad52 recombination activity by double-strand break-induced SUMO modification

31 March 2020

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Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast.

31 March 2020

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

31 March 2020

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The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus.

31 March 2020

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

31 March 2020

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

31 March 2020

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Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

31 March 2020

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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

31 March 2020

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Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

31 March 2020

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Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.

31 March 2020

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

31 March 2020

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Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

31 March 2020

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Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

31 March 2020

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Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

31 March 2020

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SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.

31 March 2020

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Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage

31 March 2020

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Human MMS21/NSE2 is a SUMO ligase required for DNA repair

31 March 2020

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31 March 2020

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

31 March 2020

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Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

31 March 2020

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

31 March 2020

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

31 March 2020

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SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

31 March 2020

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Concepts in sumoylation: a decade on

31 March 2020

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SUMOrganization of the nucleus

31 March 2020

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The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination

31 March 2020

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The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation

31 March 2020

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SUMO-targeted ubiquitin ligases in genome stability.

31 March 2020

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Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest

31 March 2020

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The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeast

31 March 2020

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The DNA replication checkpoint response stabilizes stalled replication forks

31 March 2020

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

31 March 2020

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Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks

31 March 2020

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PCNA controls establishment of sister chromatid cohesion during S phase

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2351

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PubMed ID

18285803

Dimensions Publication ID

18 August 2017

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1 reference

PubMed ID

18285803