(Q35579412)

9 August 2017

1 reference

title

Pharmacology of anticancer drugs in the elderly population (English)

1 reference

9 August 2017

Pharmacology of Anticancer Drugs in the Elderly Population (English)

1 reference

https://api.crossref.org/works/10.2165/00003088-200342140-00003

30 March 2024

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14606930

30 March 2024

author name string

Hans Wildiers

1

1 reference

9 August 2017

Martin S. Highley

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14606930

30 March 2024

Ernst A. de Bruijn

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14606930

30 March 2024

Allan T. van Oosterom

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14606930

30 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14606930

30 March 2024

publication date

1 January 2003

1 reference

Clinical Pharmacokinetics

9 August 2017

1 reference

9 August 2017

42

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9 August 2017

14

1 reference

9 August 2017

1213-1242

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https://scigraph.springernature.com/pub.10.2165/00003088-200342140-00003

9 August 2017

0 references

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Pharmacology of antineoplastic agents in older cancer patients

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Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase III trial

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Lack of age-dependent cisplatin nephrotoxicity

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Clinical pharmacokinetics of topotecan

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Clinical pharmacokinetics of paclitaxel

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Clinical pharmacology of 5-fluorouracil

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Relationship between clinical parameters and pharmacokinetics of mitomycin C

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The treatment of elderly patients with aggressive non-Hodgkin's lymphomas: feasibility and efficacy of an intensive multidrug regimen

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12 December 2020

Pharmacokinetics of oxaliplatin in patients with normal versus impaired renal function

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12 December 2020

Weekly docetaxel in the treatment of elderly patients with advanced nonsmall cell lung carcinoma. A Minnie Pearl Cancer Research Network Phase II Trial

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Role of red blood cells in pharmacokinetics of chemotherapeutic agents

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12 December 2020

Impact of age on outcome of patients with cancer undergoing autologous bone marrow transplant

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12 December 2020

Effect of liver failure on the pharmacokinetics of cyclophosphamide

1 reference

12 December 2020

Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer

1 reference

12 December 2020

Phase I trial of docetaxel administered by weekly infusion in patients with advanced refractory cancer

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12 December 2020

Bleomycin pharmacology: mechanism of action and resistance, and clinical pharmacokinetics.

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12 December 2020

Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study

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12 December 2020

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.

1 reference

12 December 2020

Mitoxantrone. A review of its pharmacology and clinical efficacy in the management of hormone-resistant advanced prostate cancer

1 reference

12 December 2020

Pharmacokinetic drug interactions of commonly used anticancer drugs.

1 reference

12 December 2020

Clinical Pharmacokinetics of Carboplatin

1 reference

12 December 2020

Oral idarubicin. A review of its pharmacological properties and clinical efficacy in the treatment of haematological malignancies and advanced breast cancer

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12 December 2020

What threshold for adjuvant therapy in older breast cancer patients?

1 reference

12 December 2020

Salivary and plasma pharmacokinetics of topotecan in patients with metastatic epithelial ovarian cancer

1 reference

12 December 2020

Clinical pharmacokinetic considerations in the elderly. An update

1 reference

12 December 2020

Evaluation of formulas using the serum creatinine level to calculate the optimal dosage of carboplatin.

1 reference

12 December 2020

The importance of dose intensity in chemotherapy of metastatic breast cancer

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12 December 2020

Randomized phase II comparison of standard CHOP with weekly CHOP in elderly patients with non-Hodgkin's lymphoma

1 reference

12 December 2020

Docetaxel versus paclitaxel for antiangiogenesis

1 reference

12 December 2020

Advanced ovarian cancer in the elderly: results of consecutive trials with cisplatin-based chemotherapy

1 reference

12 December 2020

Is it possible to use anthracyclines in patients older than 70 years? Pro.

1 reference

12 December 2020

Factors affecting the pharmacokinetics of CPT-11: the body mass index, age and sex are independent predictors of pharmacokinetic parameters of CPT-11.

1 reference

12 December 2020

Retrospective comparison of toxicity and efficacy in phase II trials of 3-h infusions of paclitaxel for patients 70 years of age or older and patients under 70 years of age

1 reference

12 December 2020

Gastrointestinal absorption as a function of age: xylose absorption in healthy adults.

1 reference

12 December 2020

Randomized trial with or without granulocyte colony-stimulating factor as adjunct to induction VNCOP-B treatment of elderly high-grade non-Hodgkin's lymphoma

1 reference

12 December 2020

Influence of sex and age on fluorouracil clearance

1 reference

12 December 2020

A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer.

1 reference

12 December 2020

Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the International Breast Cancer Study Group Trial VII.

1 reference

12 December 2020

Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial

1 reference

12 December 2020

Clinical pharmacokinetics of epirubicin.

1 reference

12 December 2020

Interactions of methotrexate and cyclophosphamide with the pharmacokinetics of 5-fluorouracil in an animal model

1 reference

12 December 2020

PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy

1 reference

12 December 2020

Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative

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12 December 2020

Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer.

1 reference

12 December 2020

Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease

1 reference

12 December 2020

Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution

1 reference

12 December 2020

Attenuated-dose idarubicin in acute myeloid leukaemia of the elderly: pharmacokinetic study and clinical results

1 reference

12 December 2020

Phase I study of docetaxel administered as a 1-hour intravenous infusion on a weekly basis

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of hydroxyurea

1 reference

12 December 2020

Cisplatin-based combination chemotherapy for elderly patients with non-small-cell lung cancer

1 reference

12 December 2020

Prospective phase II study of single-agent gemcitabine in untreated elderly patients with stage IIIB/IV non-small-cell lung cancer

1 reference

12 December 2020

Clinical pharmacokinetics of idarubicin

1 reference

12 December 2020

Assessment of the older cancer patient

1 reference

12 December 2020

Changes in the clearance of total and unbound etoposide in patients with liver dysfunction

1 reference

12 December 2020

Prospective evaluation of a model for predicting etoposide plasma protein binding in cancer patients.

1 reference

12 December 2020

Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance

1 reference

12 December 2020

Clinical pharmacokinetics of capecitabine

1 reference

12 December 2020

Effect of age on therapeutic outcome in advanced diffuse histiocytic lymphoma: the Southwest Oncology Group experience

1 reference

12 December 2020

Use of growth factors in the elderly patient with cancer: a report from the Second International Society for Geriatric Oncology (SIOG) 2001 meeting

1 reference

12 December 2020

Bioequivalence of two tablet formulations of capecitabine and exploration of age, gender, body surface area, and creatinine clearance as factors influencing systemic exposure in cancer patients

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12 December 2020

Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function

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12 December 2020

Can pharmacokinetic monitoring improve clinical use of fluorouracil?

1 reference

12 December 2020

Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients

1 reference

12 December 2020

Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites

1 reference

12 December 2020

Doxorubicin-based chemotherapy in the elderly

1 reference

12 December 2020

Low-dose fludarabine and cyclophosphamide in elderly patients with B-cell chronic lymphocytic leukemia refractory to conventional therapy

1 reference

12 December 2020

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine

1 reference

12 December 2020

Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly

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12 December 2020

Cancer pharmacology in the elderly.

1 reference

12 December 2020

The pulmonary toxicity of antineoplastic agents

1 reference

12 December 2020

Adaptive control methods for the dose individualisation of anticancer agents

1 reference

12 December 2020

Management of breast cancer in the older woman

1 reference

12 December 2020

Inter- and intrapatient variability in etoposide kinetics with oral and intravenous drug administration

1 reference

12 December 2020

Life-threatening myelosuppression in patients with occult renal impairment receiving topotecan

1 reference

12 December 2020

Cellular pharmacokinetics of daunorubicin: relationships with the response to treatment in patients with acute myeloid leukemia

1 reference

12 December 2020

Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast carcinoma

1 reference

12 December 2020

The clinical pharmacology of etoposide and teniposide

1 reference

12 December 2020

Docetaxel (Taxotere) in combination with radiation therapy and the potential of weekly administration in elderly and/or poor performance status patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Pharmacokinetics and metabolism of mitoxantrone. A review

1 reference

12 December 2020

Altered pharmacokinetics and metabolism of CPT-11 in liver dysfunction: a need for guidelines.

1 reference

12 December 2020

Plasma concentration monitoring of busulfan: does it improve clinical outcome?

1 reference

12 December 2020

Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy.

1 reference

12 December 2020

Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer

1 reference

12 December 2020

Elderly aggressive-histology non-Hodgkin's lymphoma: first-line VNCOP-B regimen experience on 350 patients.

1 reference

12 December 2020

Underrepresentation of patients 65 years of age or older in cancer-treatment trials

1 reference

12 December 2020

Can food affect the bioavailability of chlorambucil in patients with haematological malignancies?

1 reference

12 December 2020

Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer: a stopped multicentre randomised trial. Medical Research Council Lung Cancer Working Party.

1 reference

12 December 2020

Pharmacokinetic study of mitomycin C with emphasis on the influence of aging.

1 reference

12 December 2020

Clinical pharmacokinetics of nucleoside analogues: focus on haematological malignancies

1 reference

12 December 2020

Doxorubicin-based chemotherapy in elderly patients with metastatic breast cancer. Tolerance and outcome

1 reference

12 December 2020

The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group

1 reference

12 December 2020

Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group

1 reference

12 December 2020

Cost-benefit analysis of granulocyte colony-stimulating factor in the management of elderly cancer patients

1 reference

12 December 2020

The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study

1 reference

12 December 2020

The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance

1 reference

12 December 2020

Blood and plasma pharmacokinetics of vinorelbine in elderly patients with advanced metastatic cancer

1 reference

12 December 2020

Clinical pharmacokinetics of irinotecan

1 reference

12 December 2020

Gemcitabine in the treatment of elderly patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Further refinement of carboplatin dosing

1 reference

12 December 2020

A limited-sampling model for the pharmacokinetics of carboplatin administered in combination with paclitaxel

1 reference

12 December 2020

Pharmacokinetics of vinorelbine in patients with liver metastases.

1 reference

12 December 2020

Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and Leukemia Group B 9264.

1 reference

12 December 2020

Weekly low dose epirubicin in elderly cancer patients

1 reference

12 December 2020

Doxorubicin clearance in the obese

1 reference

12 December 2020

Modeling interpatient pharmacodynamic variability of etoposide.

1 reference

12 December 2020

Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients

1 reference

12 December 2020

Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastatic breast cancer

1 reference

12 December 2020

Pharmacokinetics of Navelbine oral in elderly patients

1 reference

12 December 2020

Recent developments in the pharmacology of anticancer drugs in the elderly

1 reference

12 December 2020

Pharmacology of cancer chemotherapy in the older person.

1 reference

12 December 2020

Oxaliplatin: pharmacokinetics and chronopharmacological aspects

1 reference

12 December 2020

Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP versus CNOP chemotherapy

1 reference

12 December 2020

Geriatric oncology: challenges for the new century

1 reference

12 December 2020

Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion

1 reference

12 December 2020

Ifosfamide in the elderly: clinical considerations for a better drug management.

1 reference

12 December 2020

Phase III randomized study of fluorouracil, epirubicin, and cyclophosphamide v fluorouracil, doxorubicin, and cyclophosphamide in advanced breast cancer: an Italian multicentre trial

1 reference

12 December 2020

Pharmacokinetics of anticancer agents in patients with impaired liver function

1 reference

12 December 2020

A doxorubicin-based regimen used in the treatment of elderly patients with high-grade non-Hodgkin's lymphoma

1 reference

12 December 2020

Elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy plus granulocyte-macrophage colony-stimulating factor: identification of two age subgroups with differing hematologic toxicity

1 reference

12 December 2020

Clinical pharmacokinetics of cyclophosphamide

1 reference

12 December 2020

Population pharmacokinetics of temozolomide in cancer patients

1 reference

12 December 2020

Can older cancer patients tolerate chemotherapy? A prospective pilot study.

1 reference

12 December 2020

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

12 December 2020

1 reference

12 December 2020

Renal function and the rate of disappearance of methotrexate from serum

1 reference

12 December 2020

Renal tolerance to cisplatin in patients 70 years and older

1 reference

12 December 2020

Prediction of ifosfamide/mesna associated encephalopathy

1 reference

12 December 2020

Results of a low aggressivity chemotherapy regimen (CVP/CEB) in elderly Hodgkin's disease patients

1 reference

12 December 2020

Mitoxantrone in elderly patients with advanced breast cancer: pharmacokinetics, marrow and peripheral hematopoietic progenitor cells

1 reference

12 December 2020

Pharmacokinetic drug interactions with anticancer drugs.

1 reference

12 December 2020

Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies

1 reference

12 December 2020

Bleomycin-induced pneumonitis

1 reference

12 December 2020

Vinorelbine high-affinity binding to human platelets and lymphocytes: distribution in human blood

1 reference

12 December 2020

The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture.

1 reference

12 December 2020

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

1 reference

12 December 2020

Prediction of carboplatin clearance from standard morphological and biological patient characteristics

1 reference

12 December 2020

Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial

1 reference

12 December 2020

Early and delayed clinical cardiotoxicity of doxorubicin

1 reference

12 December 2020

Aging and pharmacology

1 reference

12 December 2020

Amifostine protects normal tissues from paclitaxel toxicity while cytotoxicity against tumour cells is maintained

1 reference

12 December 2020

Population pharmacokinetics and pharmacokinetic-pharmacodynamic relationships for docetaxel

1 reference

12 December 2020

Carboplatin dosage: prospective evaluation of a simple formula based on renal function

1 reference

12 December 2020

Gemcitabine: safety profile and efficacy in non-small cell lung cancer unaffected by age

1 reference

12 December 2020

Placental transfer, lacteal transfer and plasma protein binding of gemcitabine

1 reference

12 December 2020

Predictors of response to subsequent chemotherapy in platinum pretreated ovarian cancer: a multivariate analysis of 704 patients [seecomments]

1 reference

12 December 2020

Analysis of age, estimated creatinine clearance and pretreatment hematologic parameters as predictors of fludarabine toxicity in patients treated for chronic lymphocytic leukemia: a CALGB (9011) coordinated intergroup study

1 reference

12 December 2020

Persistence of cisplatin-induced DNA interstrand crosslinking in peripheral blood mononuclear cells from elderly and young individuals

1 reference

12 December 2020

Total and free methotrexate pharmacokinetics in elderly patients with rheumatoid arthritis. A comparison with young patients

1 reference

12 December 2020

A phase II study of weekly paclitaxel in elderly patients with advanced non-small cell lung cancer

1 reference

12 December 2020

Prognosis of elderly patients with acute myelogenous leukemia: analysis of 126 AML cases

1 reference

12 December 2020

Etoposide dosage and pharmacodynamics

1 reference

12 December 2020

Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests

1 reference

12 December 2020

Effects of Vinorelbine on Quality of Life and Survival of Elderly Patients With Advanced Non-Small-Cell Lung Cancer

1 reference

12 December 2020

Dose-response effect of adjuvant chemotherapy in breast cancer

1 reference

12 December 2020

Doxorubicin-based adjuvant chemotherapy in elderly breast cancer patients: the M.D. Anderson experience, with long-term follow-up

1 reference

12 December 2020

Plasma protein binding of drugs in the elderly

1 reference

12 December 2020

High-dose methotrexate for primary CNS lymphoma in the elderly

1 reference

12 December 2020

The influence of ageing on cisplatin pharmacokinetics in lung cancer patients with normal organ function

1 reference

12 December 2020

Relation of systemic exposure to unbound etoposide and hematologic toxicity

1 reference

12 December 2020

CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma

1 reference

12 December 2020

CHOP is the standard regimen in patients > or = 70 years of age with intermediate-grade and high-grade non-Hodgkin's lymphoma: results of a randomized study of the European Organization for Research and Treatment of Cancer Lymphoma Cooperative Study

1 reference

12 December 2020

Hodgkin's disease in the elderly: improved treatment outcome with a doxorubicin-containing regimen

1 reference

12 December 2020

Effect of granulocyte colony-stimulating factor administration in elderly patients with aggressive non-Hodgkin's lymphoma treated with a pirarubicin-combination chemotherapy regimen. Groupe d'Etudes des Lymphomes de l'Adulte.

1 reference

12 December 2020

Acute myeloid leukemia in the elderly: biology and therapeutic strategies.

1 reference

12 December 2020

Creatinine clearance as a predictor of ultrafilterable platinum disposition in cancer patients treated with cisplatin: relationship between peak ultrafilterable platinum plasma levels and nephrotoxicity

1 reference

12 December 2020

Re: prediction of carboplatin clearance from standard morphological and biological patient characteristics

1 reference

12 December 2020

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO.

1 reference

12 December 2020

Geriatric Pharmacology: Basic and Clinical Considerations*

1 reference

12 December 2020

Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients

1 reference

12 December 2020

Clinical pharmacokinetics of doxorubicin

1 reference

12 December 2020

Patients aged > or = 70 are at high risk for neutropenic infection and should receive hemopoietic growth factors when treated with moderately toxic chemotherapy

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12 December 2020

Aging and cancer in America. Demographic and epidemiologic perspectives

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12 December 2020

Pharmacology of 21-day oral etoposide given in combination with i.v. cisplatin in patients with extensive-stage small cell lung cancer: a cancer and leukemia group B study (CALGB 9062).

1 reference

12 December 2020

Weekly high-dose paclitaxel in metastatic and locally advanced breast cancer: a preliminary report.

1 reference

12 December 2020

Population pharmacokinetics of topotecan: intraindividual variability in total drug.

1 reference

12 December 2020

Bioavailability of low-dose oral etoposide

1 reference

12 December 2020

The effect of age on the pharmacokinetics of ifosfamide

1 reference

12 December 2020

Pharmacokinetics of adriamycin (NSC-123127) in patients with sarcomas

1 reference

12 December 2020

Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen

1 reference

12 December 2020

The geriatric cancer patient: equal benefit from equal treatment

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12 December 2020

Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines.

1 reference

12 December 2020

Incidence of radiographically evident bone disease, nephrocalcinosis, and nephrolithiasis in various types of renal tubular acidosis

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https://api.crossref.org/works/10.2165/00003088-200342140-00003

Journal of Clinical Oncology

30 March 2024

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30 March 2024

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https://api.crossref.org/works/10.2165/00003088-200342140-00003

30 March 2024

Identifiers

1 reference

Dimensions Publication ID

9 August 2017

0 references

1 reference