(Q35581525)

9 August 2017

1 reference

title

Probing dopamine transporter structure and function by Zn2+-site engineering (English)

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9 August 2017

main subject

membrane glycoprotein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

31 March 2024

1

Claus Juul Loland

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

3

Ulrik Gether

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14612149

31 March 2024

author name string

Kristine Norgaard-Nielsen

2

1 reference

9 August 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

9 August 2017

31 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14612149

full work available at URL

31 March 2024

https://api.elsevier.com/content/article/PII:S0014299903023215?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

https://api.elsevier.com/content/article/PII:S0014299903023215?httpAccept=text/plain

31 March 2024

1 reference

https://api.crossref.org/works/10.1016/J.EJPHAR.2003.08.068

European Journal of Pharmacology

31 March 2024

published in

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9 August 2017

volume

479

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9 August 2017

issue

1-3

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9 August 2017

page(s)

187-197

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Analysis of zinc binding sites in protein crystal structures

9 August 2017

cites work

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31 March 2024

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

31 March 2024

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The galvanization of biology: a growing appreciation for the roles of zinc

31 March 2024

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External cysteine residues in the serotonin transporter

31 March 2024

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Structure and function of the dopamine transporter

31 March 2024

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Permeation and gating residues in serotonin transporter

31 March 2024

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Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor

31 March 2024

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Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

31 March 2024

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Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label

31 March 2024

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31 March 2024

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31 March 2024

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Dendrodendritic inhibition through reversal of dopamine transport

31 March 2024

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Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors

31 March 2024

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31 March 2024

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Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

31 March 2024

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Projection structure and molecular architecture of OxlT, a bacterial membrane transporter.

31 March 2024

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Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

31 March 2024

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Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

31 March 2024

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Simple Allosteric Model for Membrane Pumps

31 March 2024

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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

31 March 2024

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Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors

31 March 2024

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

31 March 2024

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Carrier-mediated release of neurotransmitters

31 March 2024

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Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+.

31 March 2024

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Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation

31 March 2024

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Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism

31 March 2024

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Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression

31 March 2024

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Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains

31 March 2024

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Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site

31 March 2024

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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

31 March 2024

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Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

31 March 2024

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Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

31 March 2024

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Osmochemistry of solute translocation

31 March 2024

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Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

31 March 2024

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Delineation of an endogenous zinc-binding site in the human dopamine transporter

31 March 2024

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Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

31 March 2024

45

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Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

31 March 2024

46

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Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons

31 March 2024

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Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

31 March 2024

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31 March 2024

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Zinc mining for protein domains

31 March 2024

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The Rat Serotonin Transporter: Identification of Cysteine Residues Important for Substrate Transport

31 March 2024

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Allosteric modulation of beta2-adrenergic receptor by Zn(2+).

31 March 2024

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Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor

31 March 2024

55

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Construction of a high affinity zinc switch in the kappa-opioid receptor.

31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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31 March 2024

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Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling: application to the lactose permease of Escherichia coli

31 March 2024

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A method for distance determination in proteins using a designed metal ion binding site and site-directed spin labeling: evaluation with T4 lysozyme

31 March 2024

63

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Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.

31 March 2024

64

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Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons

31 March 2024

65

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Three-dimensional structure of the ion-coupled transport protein NhaA.

31 March 2024

66

1 reference

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Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolution

31 March 2024

67

1 reference

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Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter

31 March 2024

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Novel tropane-based irreversible ligands for the dopamine transporter

31 March 2024

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31 March 2024

Identifiers

1 reference

9 August 2017

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