(Q35590341)

9 August 2017

title

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation (English)

1 reference

G protein-coupled receptor

9 August 2017

main subject

0 references

author name string

Daniel G Isom

series ordinal

1

1 reference

9 August 2017

Henrik G Dohlman

series ordinal

2

1 reference

9 August 2017

language of work or name

English

0 references

publication date

20 April 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

1 reference

9 August 2017

volume

112

1 reference

9 August 2017

issue

18

1 reference

9 August 2017

page(s)

5702-5707

1 reference

Structural basis for a pH-sensitive calcium leak across membranes

9 August 2017

cites work

1 reference

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12 July 2018

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12 July 2018

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12 July 2018

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Structure changes upon deprotonation of the proton release group in the bacteriorhodopsin photocycle

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Activation mechanism of the β2-adrenergic receptor

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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The structural basis of agonist-induced activation in constitutively active rhodopsin

12 July 2018

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Large shifts in pKa values of lysine residues buried inside a protein

12 July 2018

1 reference

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Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

12 July 2018

1 reference

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Charges in the hydrophobic interior of proteins

12 July 2018

1 reference

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Evolution of GPCR: change and continuity

12 July 2018

1 reference

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Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

12 July 2018

1 reference

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Rhodopsin activation switches in a native membrane environment.

12 July 2018

1 reference

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High tolerance for ionizable residues in the hydrophobic interior of proteins

12 July 2018

1 reference

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Two protonation switches control rhodopsin activation in membranes

12 July 2018

1 reference

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Crystal structure of opsin in its G-protein-interacting conformation

12 July 2018

1 reference

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

12 July 2018

1 reference

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12 July 2018

1 reference

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Proton transfers in the bacteriorhodopsin photocycle

12 July 2018

1 reference

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12 July 2018

1 reference

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12 July 2018

1 reference

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Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

12 July 2018

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

12 July 2018

1 reference

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Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

12 July 2018

1 reference

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Identification of a conserved switch residue responsible for selective constitutive activation of the beta2-adrenergic receptor

12 July 2018

1 reference

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X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

Electron-crystallographic refinement of the structure of bacteriorhodopsin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

pH-induced structural changes in bacteriorhodopsin studied by Fourier transform infrared spectroscopy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

Identification of common molecular subsequences

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

Identification of residues required for ligand binding to the beta-adrenergic receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

What are enzyme structures telling us?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

Electrostatic effects in proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

pKa of the protonated Schiff base and aspartic 85 in the bacteriorhodopsin binding site is controlled by a specific geometry between the two residues.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4426463

The Protein Model Portal--a comprehensive resource for protein structure and model information

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1417888112

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25902551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25902551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1417888112

1 reference

9 August 2017

0 references

1 reference

9 August 2017

1 reference