(Q33931569)

30 July 2017

title

Allosteric sodium in class A GPCR signaling (English)

1 reference

G protein-coupled receptor

30 July 2017

main subject

0 references

author

Vsevolod Katritch

series ordinal

1

1 reference

30 July 2017

6

1 reference

30 July 2017

4

Bryan L Roth

1 reference

30 July 2017

2

Gustavo Fenalti

1 reference

30 July 2017

5

Vadim Cherezov

1 reference

30 July 2017

3

Enrique E Abola

1 reference

30 July 2017

publication date

21 April 2014

1 reference

30 July 2017

number of pages

12

1 reference

Trends in Biochemical Sciences

inferred from page(s)

published in

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30 July 2017

volume

39

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30 July 2017

issue

5

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30 July 2017

page(s)

233-244

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Structure of the human P2Y12 receptor in complex with an antithrombotic drug

30 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

5 July 2018

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Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

5 July 2018

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Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

5 July 2018

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Structure of the human κ-opioid receptor in complex with JDTic

5 July 2018

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

5 July 2018

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Structure and dynamics of the M3 muscarinic acetylcholine receptor

5 July 2018

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

5 July 2018

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

5 July 2018

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The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi

5 July 2018

1 reference

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Diversity and modularity of G protein-coupled receptor structures

5 July 2018

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Activation mechanism of the β2-adrenergic receptor

5 July 2018

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Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors

5 July 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

5 July 2018

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

5 July 2018

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

5 July 2018

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Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

5 July 2018

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Structure of an agonist-bound human A2A adenosine receptor

5 July 2018

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Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms

5 July 2018

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Strategies to discover unexpected targets for drugs active at G protein-coupled receptors

5 July 2018

1 reference

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Induced effects of sodium ions on dopaminergic G-protein coupled receptors

5 July 2018

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Signaling by internalized G-protein-coupled receptors.

5 July 2018

1 reference

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Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Ligand binding and micro-switches in 7TM receptor structures

5 July 2018

1 reference

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

5 July 2018

1 reference

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Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Structural diversity of G protein-coupled receptors and significance for drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Signaling mechanisms of GPCR ligands

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

5 July 2018

1 reference

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Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor

5 July 2018

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

5 July 2018

1 reference

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Transduction of receptor signals by beta-arrestins

5 July 2018

1 reference

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Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.

5 July 2018

1 reference

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

5 July 2018

1 reference

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Historical review: Opioid receptors

5 July 2018

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Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

5 July 2018

1 reference

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Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

5 July 2018

1 reference

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Unmasking different constitutive activity of four chemoattractant receptors using Na+ as universal stabilizer of the inactive (R) state

5 July 2018

1 reference

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Activation of rhodopsin: new insights from structural and biochemical studies

5 July 2018

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The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover

5 July 2018

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

5 July 2018

1 reference

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Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues

5 July 2018

1 reference

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Effects of sodium on agonist efficacy for G-protein activation in mu-opioid receptor-transfected CHO cells and rat thalamus

5 July 2018

1 reference

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Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Mutagenesis of the mouse delta opioid receptor converts (-)-buprenorphine from a partial agonist to an antagonist

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Somatostatin5 receptor-mediated [35S]guanosine-5'-O-(3-thio)triphosphate binding: agonist potencies and the influence of sodium chloride on intrinsic activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Interaction of [3H]orphanin FQ and 125I-Tyr14-orphanin FQ with the orphanin FQ receptor: kinetics and modulation by cations and guanine nucleotides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Site-directed mutagenesis of the human A1 adenosine receptor: influences of acidic and hydroxy residues in the first four transmembrane domains on ligand binding

5 July 2018

1 reference

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Na+ ions binding to the bradykinin B2 receptor suppress agonist-independent receptor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

5 July 2018

1 reference

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Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic r

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

5 July 2018

1 reference

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Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Opiate agonists and antagonists discriminated by receptor binding in brain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Interactions of amiloride with alpha- and beta-adrenergic receptors: amiloride reveals an allosteric site on alpha 2-adrenergic receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Hm1 muscarinic cholinergic receptor internalization requires a domain in the third cytoplasmic loop.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

The role of water and sodium ions in the activation of the μ-opioid receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Factors governing metal-ligand distances and coordination geometries of metal complexes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Competitive and silent antagonism of recombinant 5-HT1B receptors by amiloride

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Regulation of mu-opioid receptor in neural cells by extracellular sodium

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4106411

Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

29 October 2018

1 reference

12 December 2020

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium

1 reference

12 December 2020

Regulation of dopamine D2 receptors by sodium and pH

1 reference

12 December 2020

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association

1 reference

12 December 2020

Interaction of amiloride with rat parotid muscarinic and alpha-adrenergic receptors

1 reference

12 December 2020

1 reference

12 December 2020

Mutation of Asp100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction

1 reference

12 December 2020

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

1 reference

12 December 2020

Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor

1 reference

12 December 2020

Signal transduction within G-protein coupled receptors via an ion tunnel: a hypothesis

1 reference

12 December 2020

Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors

1 reference

12 December 2020

Activation mechanism of human oxytocin receptor: a combined study of experimental and computer-simulated mutagenesis

1 reference

12 December 2020

The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor

1 reference

12 December 2020

10.1016/J.TIBS.2014.03.002

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference