(Q35595410)

9 August 2017

1 reference

title

Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype (English)

1 reference

9 August 2017

0 references

1 reference

Clare Henderson

1

1 reference

PubMed ID

14643295

9 August 2017

Claudio Brancolini

series ordinal

2

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PubMed ID

14643295

9 August 2017

language of work or name

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1 October 2003

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9 August 2017

Drug Resistance Updates

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9 August 2017

6

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9 August 2017

5

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9 August 2017

247-256

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Apoptosomes: engines for caspase activation

9 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Acetylation inactivates the transcriptional repressor BCL6.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

A unified model for apical caspase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apoptosis: mediator or mode of cell killing by anticancer agents?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Covalent modifications of histones: expression from chromatin templates.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylases (HDACs): characterization of the classical HDAC family

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Emerging connections between DNA methylation and histone acetylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apoptosis pathways: turned on their heads?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Mitochondria as targets for established and novel anti-cancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The human histone deacetylase family

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone acetylation and chromatin remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Cellular stress response and apoptosis in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Death and anti-death: tumour resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylases specifically down-regulate p53-dependent gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The role of caspase-8 in resistance to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Mitochondrial control of apoptosis: an introduction

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Deciphering the pathways of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Epigenetic changes in tumor Fas levels determine immune escape and response to therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylases and cancer: causes and therapies

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors as new cancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylases as therapeutic targets in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Molecular sequelae of histone deacetylase inhibition in human malignant B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Mitochondria: releasing power for life and unleashing the machineries of death

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Decision making by p53: life, death and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

HDAC's at work: everyone doing their part

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Chronic oral administration of CI-994: a phase 1 study

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apoptosis and disease: regulation and clinical relevance of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apoptosis is critical for drug response in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Death and decoy receptors and p53-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Mechanisms of caspase activation and inhibition during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The regulation of reactive oxygen species production during programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Histone deacetylase inhibitors in cancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

1 reference

7 January 2021

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Biochemistry and function of the DISC

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Higher-order structure of chromatin and chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1368-7646%2803%2900067-0

7 January 2021

10.1016/S1368-7646(03)00067-0

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14643295