(Q35021215)

5 August 2017

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title

Apoptosomes: engines for caspase activation (English)

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5 August 2017

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Suzanne Cory

2

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author name string

Jerry M Adams

series ordinal

1

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5 August 2017

publication date

1 December 2002

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Current Opinion in Cell Biology

5 August 2017

published in

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5 August 2017

volume

14

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5 August 2017

issue

6

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5 August 2017

page(s)

715-720

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5 August 2017

cites work

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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7 January 2021

Caspase activation: the induced-proximity model

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7 January 2021

Caspase-9 and APAF-1 form an active holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

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7 January 2021

HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator

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7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

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7 January 2021

Mechanisms of caspase activation and inhibition during apoptosis

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7 January 2021

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

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7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

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https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

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7 January 2021

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

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7 January 2021

The CARD domain: a new apoptotic signalling motif

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7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

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7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

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7 January 2021

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

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7 January 2021

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

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7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

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7 January 2021

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

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7 January 2021

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Negative regulation of the Apaf-1 apoptosome by Hsp70

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Caspase-9 can be activated without proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Dimer formation drives the activation of the cell death protease caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Adult Apaf-1-deficient mice exhibit male infertility

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

The role of ARK in stress-induced apoptosis in Drosophila cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

The Drosophila caspase DRONC is regulated by DIAP1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Altered cytochrome c display precedes apoptotic cell death in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Nods: a family of cytosolic proteins that regulate the host response to pathogens

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

CLAN, a novel human CED-4-like gene

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2802%2900381-2

7 January 2021

10.1016/S0955-0674(02)00381-2

Identifiers

DOI

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5 August 2017

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