(Q35597361)

9 August 2017

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title

Click chemistry patents and their impact on drug discovery and chemical biology (English)

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9 August 2017

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Lyn H Jones

2

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author name string

Hua Xu

series ordinal

1

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9 August 2017

language of work or name

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1 January 2015

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Pharmaceutical patent analyst

9 August 2017

published in

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9 August 2017

volume

4

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9 August 2017

issue

2

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9 August 2017

page(s)

109-119

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Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

9 August 2017

cites work

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Chemical remodelling of cell surfaces in living animals

21 January 2018

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How chemoproteomics can enable drug discovery and development

21 January 2018

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Click chemistry for drug development and diverse chemical-biology applications.

21 January 2018

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Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.

21 January 2018

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The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals

21 January 2018

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1,3-Dipolar Cycloadditions. Past and Future

21 January 2018

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

21 January 2018

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Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

21 January 2018

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Ruthenium-catalyzed cycloaddition of alkynes and organic azides

21 January 2018

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Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism

21 January 2018

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A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems

21 January 2018

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Copper-free click chemistry for dynamic in vivo imaging

21 January 2018

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Copper-free click chemistry in living animals

21 January 2018

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Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

21 January 2018

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Imaging cell surface glycans with bioorthogonal chemical reporters

21 January 2018

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Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery

21 January 2018

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A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds

21 January 2018

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Probing mucin-type O-linked glycosylation in living animals

21 January 2018

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A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation

21 January 2018

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Mechanistic investigation of the staudinger ligation

21 January 2018

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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity

21 January 2018

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Tetrazine-based cycloadditions: application to pretargeted live cell imaging

21 January 2018

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Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition

21 January 2018

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Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition

21 January 2018

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Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation

21 January 2018

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In situ synthesis of alkenyl tetrazines for highly fluorogenic bioorthogonal live-cell imaging probes

21 January 2018

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Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging.

21 January 2018

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Tetrazine-trans-cyclooctene ligation for the rapid construction of integrin αvβ₃ targeted PET tracer based on a cyclic RGD peptide

21 January 2018

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Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method.

21 January 2018

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Target validation using chemical probes

21 January 2018

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

21 January 2018

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Protein modification, bioconjugation, and disulfide bridging using bromomaleimides

21 January 2018

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A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

21 January 2018

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Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

21 January 2018

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Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

21 January 2018

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Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

21 January 2018

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Dual-surface modification of the tobacco mosaic virus

21 January 2018

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Addition of the keto functional group to the genetic code of Escherichia coli.

21 January 2018

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Introducing genetically encoded aldehydes into proteins

21 January 2018

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Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag

21 January 2018

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N-terminal labeling of proteins by the Pictet-Spengler reaction

21 January 2018

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A Pictet-Spengler ligation for protein chemical modification

21 January 2018

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A biocompatible condensation reaction for controlled assembly of nanostructures in living cells.

21 January 2018

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Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry.

21 January 2018

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SuFEx-based synthesis of polysulfates

21 January 2018

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Click-enabled heterotrifunctional template for sequential bioconjugations

21 January 2018

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Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/PPA.14.59

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release_q7xnbhmrrncp7hvhbacelwmm3q

9 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/q7xnbhmrrncp7hvhbacelwmm3q

mapped directly with Wikidata item

24 November 2022

based on heuristic

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