(Q35600013)

9 August 2017

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title

Glia: a novel drug discovery target for clinical pain (English)

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9 August 2017

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Linda R Watkins

1

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9 August 2017

Steven F Maier

series ordinal

2

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9 August 2017

publication date

1 December 2003

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Nature Reviews Drug Discovery

9 August 2017

published in

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9 August 2017

volume

2

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9 August 2017

issue

12

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9 August 2017

page(s)

973-985

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https://scigraph.springernature.com/pub.10.1038/nrd1251

9 August 2017

exact match

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cites work

Anticonvulsant drugs for management of pain: a systematic review.

1 reference

A systematic review of antidepressants in neuropathic pain

31 March 2020

1 reference

Beyond neurons: evidence that immune and glial cells contribute to pathological pain states

31 March 2020

1 reference

Neuronal plasticity: increasing the gain in pain

31 March 2020

1 reference

Astrocytic intermediate filaments: lessons from GFAP and vimentin knock-out mice

31 March 2020

1 reference

Tripartite synapses: glia, the unacknowledged partner

31 March 2020

1 reference

Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury.

31 March 2020

1 reference

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

31 March 2020

1 reference

Glial activation: a driving force for pathological pain

31 March 2020

1 reference

Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex.

31 March 2020

1 reference

Selective inhibition of glial cell metabolism in vivo by fluorocitrate.

31 March 2020

1 reference

Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia

31 March 2020

1 reference

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

31 March 2020

1 reference

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.

31 March 2020

1 reference

Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.

31 March 2020

1 reference

Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.

31 March 2020

1 reference

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

31 March 2020

1 reference

A phosphoinositide-linked peptide response in astrocytes: evidence for regional heterogeneity

31 March 2020

1 reference

Marked Regional Heterogeniety of125I-Bolton Hunter Substance P Binding and Substance P-Induced Activation of Phospholipase C in Astrocyte Cultures from the Embryonic or Newborn Rat

31 March 2020

1 reference

Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.

31 March 2020

1 reference

Connexin-43 in rat spinal cord: localization in astrocytes and identification of heterotypic astro-oligodendrocytic gap junctions

31 March 2020

1 reference

Activation of fibres in rat sciatic nerve alters phosphorylation state of connexin-43 at astrocytic gap junctions in spinal cord: evidence for junction regulation by neuronal-glial interactions.

31 March 2020

1 reference

Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production.

31 March 2020

1 reference

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

31 March 2020

1 reference

Pluripotential hemopoietic stem cells in adult mouse brain

31 March 2020

1 reference

Mature microglia resemble immature antigen-presenting cells

31 March 2020

1 reference

Gliogenesis in the central nervous system

31 March 2020

1 reference

Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists

31 March 2020

1 reference

Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.

31 March 2020

1 reference

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

31 March 2020

1 reference

Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage

31 March 2020

1 reference

Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition

31 March 2020

1 reference

Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model

31 March 2020

1 reference

Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat.

31 March 2020

1 reference

Induction of nociceptive responses by intrathecal injection of interleukin-1 in mice

31 March 2020

1 reference

Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain

31 March 2020

1 reference

Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

31 March 2020

1 reference

Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing

31 March 2020

1 reference

Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia

31 March 2020

1 reference

Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons

31 March 2020

1 reference

Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats

31 March 2020

1 reference

Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment

31 March 2020

1 reference

Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica

31 March 2020

1 reference

The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve

31 March 2020

1 reference

Thalidomide treatment in chronic constrictive neuropathy decreases endoneurial tumor necrosis factor-alpha, increases interleukin-10 and has long-term effects on spinal cord dorsal horn met-enkephalin

31 March 2020

1 reference

Clinical pharmacology of thalidomide.

31 March 2020

1 reference

Thalidomide neurotoxicity

31 March 2020

1 reference

Interleukin-10 and the interleukin-10 receptor

31 March 2020

1 reference

Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE

31 March 2020

1 reference

Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats

31 March 2020

1 reference

Cytokine involvement in dynorphin-induced allodynia

31 March 2020

1 reference

Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat.

31 March 2020

1 reference

Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord

31 March 2020

1 reference

Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons

31 March 2020

1 reference

Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials

31 March 2020

1 reference

Neuromodulatory effect of propentofylline on rat brain under acute and long-term hypoperfusion

31 March 2020

1 reference

Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion.

31 March 2020

1 reference

Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet

31 March 2020

1 reference

Cascading glia reactions: a common pathomechanism and its differentiated control by cyclic nucleotide signaling

31 March 2020

1 reference

Protective mechanisms of adenosine in neurons and glial cells

31 March 2020

1 reference

Adenosine in the spinal cord and periphery: release and regulation of pain

31 March 2020

1 reference

Differential regulation of microglial activation by propentofylline via cAMP signaling.

31 March 2020

1 reference

Thalidomide: A review of approved and investigational uses

31 March 2020

1 reference

Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester

31 March 2020

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Thalidomide inhibits tumor necrosis factor-alpha production by lipopolysaccharide- and lipoarabinomannan-stimulated human microglial cells

31 March 2020

1 reference

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation

31 March 2020

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Thalidomide reduces tumour necrosis factor alpha and interleukin 12 production in patients with chronic active Crohn's disease

31 March 2020

1 reference

Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells

31 March 2020

1 reference

Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide

31 March 2020

1 reference

Complete resolution of reflex sympathetic dystrophy with thalidomide treatment

31 March 2020

1 reference

Leflunomide for the treatment of rheumatoid arthritis and autoimmunity

31 March 2020

1 reference

Innovative treatment approaches for rheumatoid arthritis. Cyclosporin, leflunomide and nitrogen mustard

31 March 2020

1 reference

Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirt

31 March 2020

1 reference

Active leflunomide metabolite inhibits interleukin 1beta, tumour necrosis factor alpha, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures

31 March 2020

1 reference

Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis

31 March 2020

1 reference

Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis

31 March 2020

1 reference

Mechanism of action for leflunomide in rheumatoid arthritis

31 March 2020

1 reference

Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

31 March 2020

1 reference

Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes

31 March 2020

1 reference

Adjuvant-induced arthritis: IL-1 beta, IL-6 and TNF-alpha are up-regulated in the spinal cord

31 March 2020

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Effect of Methotrexate on Glial Fibrillary Acidic Protein Content of Astrocytes in Primary Culture

31 March 2020

1 reference

Light and electron microscopic observations on the cerebellum of guinea pigs following low-dose methotrexate.

31 March 2020

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Molecular action of methotrexate in inflammatory diseases

31 March 2020

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The antiinflammatory effects of methotrexate are mediated by adenosine

31 March 2020

1 reference

Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat ad

31 March 2020

1 reference

Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression

31 March 2020

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Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4.

31 March 2020

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The effects of methotrexate on the production and activity of interleukin-1

31 March 2020

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Rescue of interleukin-1 activity by leucovorin following inhibition by methotrexate in a murine in vitro system

31 March 2020

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Morphologic alterations in rat brain following systemic and intraventricular methotrexate injection: light and electron microscopic studies.

31 March 2020

1 reference

Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease

31 March 2020

1 reference

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

31 March 2020

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Activation of astrocyte intracellular signaling pathways by interleukin-1 in rat primary striatal cultures

31 March 2020

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Gö6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation

31 March 2020

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p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

31 March 2020

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Analysis of pain markers and epidural fibrosis caused by repeated spinal surgery in Sprague-Dawley rats

31 March 2020

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Regulation of macrophage gene expression by pro- and anti-inflammatory cytokines

31 March 2020

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Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

31 March 2020

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The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.

31 March 2020

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Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia

31 March 2020

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Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity.

31 March 2020

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Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier.

31 March 2020

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Viral vectors for gene delivery to the nervous system

31 March 2020

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Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1251

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9 August 2017

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