(Q35601503)

English

A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice.

scientific article published on May 2008

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18483265%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18483265%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

based on heuristic

inferred from title

tumour xenograft

1 reference

based on heuristic

inferred from title

3

1 reference

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7 January 2020

author name string

Rebecca Kinkade

1

1 reference

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7 January 2020

Piyali Dasgupta

2

1 reference

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7 January 2020

Daniele Pernazza

4

1 reference

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7 January 2020

Melanie Carless

5

1 reference

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7 January 2020

Smitha Pillai

6

1 reference

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7 January 2020

Nicholas Lawrence

7

1 reference

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7 January 2020

Said M Sebti

8

1 reference

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7 January 2020

Srikumar Chellappan

9

1 reference

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7 January 2020

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publication date

1 May 2008

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7 January 2020

Cancer Research

1 reference

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7 January 2020

68

1 reference

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7 January 2020

3810-3818

1 reference

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7 January 2020

10

1 reference

Europe PubMed Central

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7 January 2020

A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway

1 reference

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12 July 2018

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

1 reference

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

1 reference

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12 July 2018

Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression

1 reference

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12 July 2018

Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways

1 reference

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12 July 2018

p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control

1 reference

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12 July 2018

Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes

1 reference

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12 July 2018

Raf: a strategic target for therapeutic development against cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The E2F transcriptional network: old acquaintances with new faces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Pocket proteins and cell cycle control

1 reference

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12 July 2018

Raf kinase as a target for anticancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Raf-1 regulates Rho signaling and cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The role of Raf kinases in malignant transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Building a better Trap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Targeted delivery of mutant Raf kinase to neovessels causes tumor regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Mutations of the BRAF gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The genetics of the E2F family of transcription factors: shared functions and unique roles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Sibling rivalry in the E2F family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The Rb/E2F pathway and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The retinoblastoma protein is linked to the activation of Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Cell cycle targets of the DNA tumor viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

Cell cycle: regulatory events in G1-->S transition of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

The retinoblastoma protein and cell cycle control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233839

12 July 2018

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1 reference

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12 July 2018

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

1 reference

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12 July 2018

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

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A new ex vivo model to study venous angiogenesis and arterio-venous anastomosis formation

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The sponge/Matrigel angiogenesis assay.

1 reference

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1 reference

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26 September 2018

Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.

1 reference

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26 September 2018

Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.

1 reference

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26 September 2018

Control of the G1/S transition

1 reference

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26 September 2018

Role of Raf in vascular protection from distinct apoptotic stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483265

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483265

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN gene therapy induces growth inhibition and increases efficacy of chemotherapy in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483265

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ins and outs of RB: coupling gene expression to the cell cycle clock

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483265

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18483265

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-07-6672

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18483265%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18483265%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18483265%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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