(Q35613713)

9 August 2017

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title

Idiosyncratic toxicity: the role of toxicophores and bioactivation (English)

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9 August 2017

Dominic P Williams

1

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ORCID Public Data File 2021

author name string

B Kevin Park

series ordinal

2

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9 August 2017

publication date

1 November 2003

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9 August 2017

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9 August 2017

volume

8

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9 August 2017

issue

22

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9 August 2017

page(s)

1044-1050

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Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

9 August 2017

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7 January 2021

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7 January 2021

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity

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7 January 2021

The safety of newly approved medicines: do recent market removals mean there is a problem?

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7 January 2021

Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?

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7 January 2021

Bromobenzene Metabolism and Hepatic Necrosis

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7 January 2021

Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro

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7 January 2021

Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles

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7 January 2021

Bromobenzene and p-bromophenol toxicity and covalent binding in vivo

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7 January 2021

The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice

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7 January 2021

The contribution of bromobenzene to our current understanding of chemically-induced toxicities

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7 January 2021

Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

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7 January 2021

Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection

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7 January 2021

Drug specific cytotoxic T-cells in the skin lesions of a patient with toxic epidermal necrolysis.

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7 January 2021

T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction

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7 January 2021

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

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7 January 2021

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

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7 January 2021

Xenobiotic acyl glucuronides and acyl CoA thioesters as protein-reactive metabolites with the potential to cause idiosyncratic drug reactions

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7 January 2021

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7 January 2021

Diclofenac induced hepatitis. 3 cases with features of autoimmune chronic active hepatitis

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7 January 2021

Hepatic necrosis caused by furosemide

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7 January 2021

The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity

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7 January 2021

Hepatotoxicity of DR-3438, tienilic acid, indacrinone and furosemide studied in vitro

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7 January 2021

Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis

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7 January 2021

Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development

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7 January 2021

Potentiation of the toxic effects of acetaminophen in mice by concurrent infection with influenza B virus: a possible mechanism for human Reye's syndrome?

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7 January 2021

Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?

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7 January 2021

Functional antioxidant responsive elements.

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7 January 2021

Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.

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7 January 2021

Gene expression in liver after toxic injury: analysis of heat shock response and oxidative stress-inducible genes

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7 January 2021

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

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7 January 2021

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

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7 January 2021

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

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7 January 2021

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

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7 January 2021

Expression profiling of acetaminophen liver toxicity in mice using microarray technology

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7 January 2021

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

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7 January 2021

Modulation of gene and protein expression by carbon tetrachloride in the rat liver

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7 January 2021

New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

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7 January 2021

Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system

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7 January 2021

Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury

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7 January 2021

Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats.

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7 January 2021

Dose dependence of covalent binding of acrylonitrile to tissue protein and globin in rats.

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7 January 2021

Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902888-5

7 January 2021

10.1016/S1359-6446(03)02888-5

Identifiers

DOI

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9 August 2017

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