(Q34088814)

30 July 2017

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title

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity (English)

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30 July 2017

Park BK

1

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30 July 2017

Kitteringham NR

series ordinal

2

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30 July 2017

Powell H

series ordinal

3

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30 July 2017

Pirmohamed M

series ordinal

4

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30 July 2017

language of work or name

English

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publication date

1 November 2000

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30 July 2017

22

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inferred from page(s)

published in

Toxicology

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30 July 2017

153

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30 July 2017

39-60

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30 July 2017

1-3

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New aspects on antigens in penicillin allergy

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Dendritic cells and the control of immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Selective acetaminophen metabolite binding to hepatic and extrahepatic proteins: an in vivo and in vitro analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Penicillin Allergy: The Formation of the Penicilloyl Determinant

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Metabolic basis for the pulmonary Clara cell as a target for pulmonary carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Drug-protein conjugates--XVII. The effect of storage on the antigenicity and immunogenicity of benzylpenicillin in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Some immunochemical properties of penicillenic acid. An antigenic determinant derived from penicillin

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI).

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Natural adjuvants: endogenous activators of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Quantitation of cytokine mRNA expression as an endpoint for prediction and diagnosis of xenobiotic-induced hypersensitivity reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Mechanism of acetaminophen-induced hepatotoxicity: covalent binding versus oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

New active substances authorized in the United Kingdom between 1972 and 1994.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Induction of liver-associated transforming growth factor beta 1 (TGF-beta 1) mRNA expression by carbon tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The role of antigen-presenting cells in the regulation of allergen-specific T cell responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Regulation of gamma-glutamylcysteine synthetase expression in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Studies on the mechanism of the formation of the penicillin antigen. III. The N-(D-alpha-benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Immunochemical Mechanisms of Penicillin Induced Coombs Positivity and Hemolytic Anemia in Man

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Remission of experimental autoimmune hepatitis is associated with antigen-specific and non-specific immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Studies with human and rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Tolerance, danger, and the extended family

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Induction of apoptosis by remoxipride metabolites in HL60 and CD34+/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Acetaminophen toxicity. Opposite effects of two forms of glutathione peroxidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Cytokine production by CD4+ and CD8+ T cells in mice following primary exposure to chemical allergens: evidence for functional differentiation of T lymphocytes in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Drug disposition and drug hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Coombs-positive hemolytic anemia caused by penicillin administration

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Role of T cells in drug allergies

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Adverse drug reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The immunologic and metabolic basis of drug hypersensitivities

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Reactive metabolites from the bioactivation of toxic methylfurans

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Paracetamol hepatotoxicity in metallothionein-null mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Severe adverse cutaneous reactions to drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Lamotrigine-associated anticonvulsant hypersensitivity syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Evidence in vivo for elevation of intracellular free Ca2+ in the liver after diquat, acetaminophen, and CCl4

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Alkylation of the liver plasma membrane and inhibition of the Ca2+ ATPase by acetaminophen

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Drug intolerance in HIV disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

CYP4B1 activates 4-ipomeanol in rat lung

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Lamotrigine and toxic epidermal necrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10, 11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-483X%2800%2900303-6

7 January 2021

10.1016/S0300-483X(00)00303-6

Identifiers

DOI

1 reference

30 July 2017

1 reference