(Q35617077)

9 August 2017

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title

Small-molecule MDM2-p53 inhibitors: recent advances (English)

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9 August 2017

Bian Zhang

1

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9 August 2017

Bernard T Golding

series ordinal

2

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9 August 2017

Ian R Hardcastle

series ordinal

3

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9 August 2017

1 January 2015

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Future Medicinal Chemistry

9 August 2017

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9 August 2017

7

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9 August 2017

5

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9 August 2017

631-645

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Cancer. p53, guardian of the genome

9 August 2017

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Post-translational modification of p53 in tumorigenesis

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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Patented inhibitors of p53-Mdm2 interaction (2006 - 2008).

21 January 2018

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The p53-MDM2/MDMX axis - A chemotype perspective

21 January 2018

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Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).

21 January 2018

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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

21 January 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

21 January 2018

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Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold

21 January 2018

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Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

21 January 2018

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Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

21 January 2018

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A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.

21 January 2018

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Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

21 January 2018

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Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

21 January 2018

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

21 January 2018

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The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction

21 January 2018

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Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction

21 January 2018

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

21 January 2018

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Ordering of the N-terminus of human MDM2 by small molecule inhibitors

21 January 2018

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Structure-based design of novel inhibitors of the MDM2-p53 interaction

21 January 2018

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Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

21 January 2018

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Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres

21 January 2018

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Rational design and binding mode duality of MDM2-p53 inhibitors

21 January 2018

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Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.15.13

1 reference

release_dkpu6orvxzg53fj4cpnxzvyoqi

9 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dkpu6orvxzg53fj4cpnxzvyoqi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference