(Q35623092)

9 August 2017

title

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma (English)

1 reference

9 August 2017

6

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9 August 2017

D Mahalingam

1

1 reference

9 August 2017

C M Espitia

2

1 reference

9 August 2017

E C Medina

3

1 reference

9 August 2017

J A Esquivel

4

1 reference

9 August 2017

K R Kelly

5

1 reference

9 August 2017

G Choy

7

1 reference

9 August 2017

P Taverna

8

1 reference

9 August 2017

J S Carew

9

1 reference

9 August 2017

F J Giles

10

1 reference

9 August 2017

S T Nawrocki

11

1 reference

9 August 2017

language of work or name

English

0 references

publication date

20 October 2011

1 reference

British Journal of Cancer

9 August 2017

published in

1 reference

9 August 2017

volume

105

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9 August 2017

issue

10

1 reference

9 August 2017

page(s)

1563-1573

1 reference

describes a project that uses

9 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3242528/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/bjc.2011.426

0 references

cites work

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12 July 2018

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Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells

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PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis

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12 July 2018

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Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

12 July 2018

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Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

12 July 2018

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Pim kinase-dependent inhibition of c-Myc degradation

12 July 2018

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The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

12 July 2018

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HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

12 July 2018

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12 July 2018

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

12 July 2018

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12 July 2018

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Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

12 July 2018

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Opportunities and obstacles to combination targeted therapy in renal cell cancer.

12 July 2018

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The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

12 July 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

12 July 2018

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12 July 2018

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12 July 2018

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Myc pathways provoking cell suicide and cancer

12 July 2018

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Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

12 July 2018

1 reference

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer

12 July 2018

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c-MYC: more than just a matter of life and death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

A new mathematical model for relative quantification in real-time RT-PCR

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

12 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Developmental expression of pim kinases suggests functions also outside of the hematopoietic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Sunitinib, an orally available receptor tyrosine kinase inhibitor, induces monocytic differentiation of acute myelogenous leukemia cells that is enhanced by 1,25-dihydroxyvitamin D(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

The activity of sunitinib against gastrointestinal stromal tumor seems to be distinct from its antiangiogenic effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.426

Targeting PIM kinase activity significantly augments the efficacy of cytarabine.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242528

E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22015557

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Kidney cancer: now available in a new flavor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22015557

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BJC.2011.426

1 reference

9 August 2017

1 reference

9 August 2017

1 reference