(Q35623320)

9 August 2017

title

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer (English)

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9 August 2017

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Alison Motsinger-Reif

2

object named as

A A Motsinger-Reif

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9 August 2017

F Thomas

1

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9 August 2017

J M Hoskins

3

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9 August 2017

A Dvorak

4

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9 August 2017

S Roy

5

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9 August 2017

A Alyasiri

6

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9 August 2017

R J Myerson

7

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9 August 2017

J W Fleshman

8

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9 August 2017

B R Tan

9

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9 August 2017

H L McLeod

10

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9 August 2017

language of work or name

English

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publication date

1 November 2011

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British Journal of Cancer

9 August 2017

published in

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9 August 2017

volume

105

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9 August 2017

issue

11

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9 August 2017

page(s)

1654-1662

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Thymidylate synthase genotype-directed neoadjuvant chemoradiation for patients with rectal adenocarcinoma.

9 August 2017

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27 July 2018

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27 July 2018

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Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics

27 July 2018

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C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation

27 July 2018

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27 July 2018

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27 July 2018

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Preoperative versus postoperative chemoradiotherapy for rectal cancer

27 July 2018

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First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin

27 July 2018

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A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

27 July 2018

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A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity

27 July 2018

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Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA.

27 July 2018

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Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.

27 July 2018

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Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer.

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Chemotherapy with preoperative radiotherapy in rectal cancer

21 January 2018

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Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer

21 January 2018

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The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer

21 January 2018

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The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer

21 January 2018

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Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma

21 January 2018

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21 January 2018

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Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.

21 January 2018

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Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2.

21 January 2018

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Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203.

21 January 2018

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Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.

21 January 2018

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Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.

21 January 2018

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Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012.

21 January 2018

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5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.442

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FBJC.2011.442

Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03.

21 January 2018

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Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBJC.2011.442

Detection of the G>C SNP and rare mutations in the 28-bp repeat of TYMS using gel-based capillary electrophoresis.

21 January 2018

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Schedule-dependent inhibition of thymidylate synthase by 5-fluorouracil in gastric cancer

21 January 2018

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Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients

21 January 2018

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Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial

21 January 2018

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Pyrosequencing of clinically relevant polymorphisms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242600

Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242600

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242600

Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242600

Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers

25 September 2018

1 reference

12 December 2020

T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival

1 reference

12 December 2020

A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision

1 reference

12 December 2020

Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase

1 reference

12 December 2020

Pharmacogenetics of capecitabine in advanced breast cancer patients

1 reference

12 December 2020

A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation

1 reference

12 December 2020

Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy

1 reference

12 December 2020

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

1 reference

12 December 2020

Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJC.2011.442

1 reference

Dimensions Publication ID

9 August 2017

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1 reference

9 August 2017

1 reference