(Q43053804)

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Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.

scientific article published in June 2010

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scholarly article

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3 February 2020

Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response (English)

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3 February 2020

chemoradiotherapy

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Ángel Carracedo

7

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3 February 2020

Goretti Durán Piñeiro

2

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3 February 2020

Maria Jesus Lamas

3

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3 February 2020

Antonio Gómez-Caamaño

4

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3 February 2020

Francisco Barros

8

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3 February 2020

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Emilia Balboa

1

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3 February 2020

Catuxa Celeiro-Muñoz

5

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3 February 2020

Rafael Lopez

6

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3 February 2020

publication date

1 June 2010

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3 February 2020

Pharmacogenomics

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3 February 2020

11

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3 February 2020

6

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3 February 2020

747-761

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3 February 2020

Preoperative versus postoperative chemoradiotherapy for rectal cancer

1 reference

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Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: correlation with rectal cancer regression grade

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Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study.

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21 January 2018

Phase I trial of neoadjuvant chemoradiotherapy (CRT) with capecitabine and weekly irinotecan followed by laparoscopic total mesorectal excision (LTME) in rectal cancer patients

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Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer.

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21 January 2018

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study

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21 January 2018

5-Fluorouracil: mechanisms of resistance and reversal strategies

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The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene

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21 January 2018

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

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21 January 2018

Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil

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21 January 2018

Role of cell cycle in mediating sensitivity to radiotherapy

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21 January 2018

Genome maintenance mechanisms for preventing cancer

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21 January 2018

XRCC1 and DNA strand break repair

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21 January 2018

Regulation and mechanisms of mammalian double-strand break repair

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21 January 2018

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks

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21 January 2018

ERCC1-XPF endonuclease facilitates DNA double-strand break repair

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21 January 2018

Cytogenetic evidence for differences in DNA incision activity in xeroderma pigmentosum group A, C and D cells after X-irradiation during G2 phase

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21 January 2018

DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions

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21 January 2018

Pharmacogenetics and biomarkers in colorectal cancer

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21 January 2018

Pharmacogenetics and pharmacogenomics of anticancer agents.

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21 January 2018

Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy

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21 January 2018

Biomarkers for response to neoadjuvant chemoradiation for rectal cancer

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21 January 2018

High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction

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21 January 2018

Thymidylate synthase genotypes and tumour regression in stage II/III rectal cancer patients after neoadjuvant fluorouracil-based chemoradiation

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21 January 2018

Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling

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21 January 2018

MAPK pathways in radiation responses

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Different mechanisms in the tumorigenesis of proximal and distal colon cancers

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21 January 2018

Predominance of CIN versus MSI in the development of rectal cancer at young age.

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21 January 2018

Two colons-two cancers: paradigm shift and clinical implications

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21 January 2018

Colorectal cancer, one entity or three

1 reference

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21 January 2018

A comparison of colon and rectal somatic DNA alterations

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21 January 2018

Genetic instabilities in human cancers

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21 January 2018

An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.

1 reference

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21 January 2018

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

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21 January 2018

C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation

1 reference

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21 January 2018

Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

1 reference

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21 January 2018

Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy

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21 January 2018

Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer

1 reference

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21 January 2018

Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers

1 reference

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21 January 2018

Somatic pharmacogenomics in cancer

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Using germline genotype in cancer pharmacogenetic studies

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21 January 2018

Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity

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21 January 2018

Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene

1 reference

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21 January 2018

Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer

1 reference

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21 January 2018

Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.

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Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy

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Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.

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Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.

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Identifiers

10.2217/PGS.10.51

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20504250%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20504250%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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