(Q37270356)

19 August 2017

3 references

26 October 2020

20 October 2022

5-Fluorouracil: mechanisms of resistance and reversal strategies (English)

1 reference

antineoplastic resistance

19 August 2017

1 reference

26 October 2020

1 reference

Ning Zhang

1

1 reference

19 August 2017

Ying Yin

series ordinal

2

1 reference

19 August 2017

Sheng-Jie Xu

series ordinal

3

1 reference

19 August 2017

Wei-Shan Chen

series ordinal

4

1 reference

19 August 2017

language of work or name

English

0 references

publication date

5 August 2008

3 references

19 August 2017

26 October 2020

20 October 2022

2 references

19 August 2017

26 October 2020

13

1 reference

19 August 2017

8

1 reference

19 August 2017

1551-1569

1 reference

Creative Commons Attribution

19 August 2017

2 references

26 October 2020

20 October 2022

0 references

5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

A new polymorph of 5-fluorouracil found following computational crystal structure predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Metabolism and mechanism of action of 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in Chinese cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Thymidyl biosynthesis enzymes as antibiotic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Structure of the Y94F mutant of Escherichia coli thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

5-Fluorouracil: mechanisms of action and clinical strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Advances in chemotherapy against advanced or metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Human pancreatic carcinoma cells secrete bioactive interleukin-18 after treatment with 5-fluorouracil: implications for anti-tumor immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Thymidylate synthase and dihydropyrimidine dehydrogenase are related to histological effects of 5-fluorouracil and cisplatin neoadjuvant chemotherapy for primary gastric cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Molecular mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Screening for dihydropyrimidine dehydrogenase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Acquired resistance of pancreatic cancer cells towards 5-Fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Structure-based studies on species-specific inhibition of thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Structural determinants for the intracellular degradation of human thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Enhancement of 5-fluorouracil's anticancer activity by dipyridamole

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

The mismatch repair complex hMutS alpha recognizes 5-fluorouracil-modified DNA: implications for chemosensitivity and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Characterization of cell death events induced by anti-neoplastic drugs cisplatin, paclitaxel and 5-fluorouracil on human hepatoma cell lines: Possible mechanisms of cell resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

5-Fluorouracil prevents lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells by inhibiting Akt-dependent nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Drug resistance to 5-FU linked to reactive oxygen species modulator 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Biochemical modulation of 5-fluorouracil with interferon alpha/beta and gamma on murine renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Regulation of MDK expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

DNA microarray analysis of the correlation between gene expression patterns and acquired resistance to 5-FU/cisplatin in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Identification of consensus genes and key regulatory elements in 5-fluorouracil resistance in gastric and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Synthesis and biological evaluation of new 4beta-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Synthesis and bioevaluation of 5-fluorouracil derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Reversal effect of tyroservatide (YSV) tripeptide on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resistant human colon carcinoma LoVo/5-FU cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13081551

Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

21 January 2018

1 reference

12 December 2020

p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines

1 reference

12 December 2020

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil

1 reference

12 December 2020

Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells

1 reference

12 December 2020

Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer

1 reference

12 December 2020

The interaction of thymidylate synthase expression with p53-regulated signaling pathways in tumor cells

1 reference

12 December 2020

5-fluorouracil: a pharmacological paradigm in the use of cytotoxics

1 reference

12 December 2020

Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance

1 reference

12 December 2020

Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins

1 reference

12 December 2020

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1 reference

12 December 2020

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

1 reference

12 December 2020

Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.

1 reference

12 December 2020

hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil

1 reference

12 December 2020

Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft

1 reference

12 December 2020

New concepts for the development and use of antifolates

1 reference

12 December 2020

Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity

1 reference

12 December 2020

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1 reference

12 December 2020

Cell cycle perturbation and acquired 5-fluorouracil chemoresistance.

1 reference

12 December 2020

Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats

1 reference

12 December 2020

Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells

1 reference

12 December 2020

Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.

1 reference

12 December 2020

In vitro and in vivo reversal of resistance to 5-fluorouracil in colorectal cancer cells with a novel stealth double-liposomal formulation

1 reference

12 December 2020

Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil.

1 reference

12 December 2020

Evidence for distinct DNA- and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae

1 reference

12 December 2020

Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma

1 reference

12 December 2020

Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells.

1 reference

12 December 2020

Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity.

1 reference

12 December 2020

The effect of histidine on the structure and antitumor activity of metal-5-halouracil complexes

1 reference

12 December 2020

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1 reference

12 December 2020

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death

1 reference

12 December 2020

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1 reference

12 December 2020

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

1 reference

12 December 2020

Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells

1 reference

12 December 2020

Orotate phosphoribosyltransferase levels measured by a newly established enzyme-linked immunosorbent assay in gastric carcinoma

1 reference

12 December 2020

Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.

1 reference

12 December 2020

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

1 reference

12 December 2020

Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line

1 reference

12 December 2020

Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer.

1 reference

12 December 2020

Human thymidylate synthetase. II. Derivatives of pteroylmono- and -polyglutamates as substrates and inhibitors

1 reference

12 December 2020

10.3390/MOLECULES13081551

Identifiers

DOI

1 reference

19 August 2017

0 references

1 reference