(Q35660658)

9 August 2017

title

Aberrant signaling pathways in pancreatic cancer: a two compartment view (English)

1 reference

Martín E Fernández-Zapico

9 August 2017

1 reference

series ordinal

3

object named as

Martin E Fernandez-Zapico

1 reference

9 August 2017

author name string

Angela L McCleary-Wheeler

series ordinal

1

1 reference

9 August 2017

Robert McWilliams

series ordinal

2

1 reference

9 August 2017

publication date

1 January 2012

1 reference

9 August 2017

published in

Molecular Carcinogenesis

1 reference

9 August 2017

volume

51

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9 August 2017

issue

1

1 reference

9 August 2017

page(s)

25-39

1 reference

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

9 August 2017

cites work

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27 July 2018

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27 July 2018

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27 July 2018

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Epidermal growth factor receptor regulates pancreatic fibrosis

27 July 2018

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SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

27 July 2018

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

27 July 2018

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27 July 2018

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Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer

27 July 2018

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Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

27 July 2018

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

27 July 2018

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Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition.

27 July 2018

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

27 July 2018

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Rational targeting of Notch signaling in cancer

27 July 2018

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A paracrine requirement for hedgehog signalling in cancer

27 July 2018

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Pancreatic stellate cells: partners in crime with pancreatic cancer cells

27 July 2018

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

27 July 2018

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Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.

27 July 2018

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Pancreatic cancer-associated stroma production

27 July 2018

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Basics of TGF-beta and pancreatic cancer

27 July 2018

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Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia

27 July 2018

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Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia

27 July 2018

1 reference

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Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells

27 July 2018

1 reference

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Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

27 July 2018

1 reference

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Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Stromal biology of pancreatic cancer

27 July 2018

1 reference

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The pancreatic stellate cell: a star on the rise in pancreatic diseases

27 July 2018

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Hedgehog/Ras interactions regulate early stages of pancreatic cancer

27 July 2018

1 reference

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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

27 July 2018

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Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

27 July 2018

1 reference

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Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma

27 July 2018

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Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy

27 July 2018

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Osteonectin influences growth and invasion of pancreatic cancer cells

27 July 2018

1 reference

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Precursors to invasive pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Overexpression of TGF-beta by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Increased expression of NF-kappa B subunits in human pancreatic cancer cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Mouse models of pancreatic cancer: the fur is finally flying!

27 July 2018

1 reference

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays

27 July 2018

1 reference

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Function of nuclear factor kappaB in pancreatic cancer metastasis

27 July 2018

1 reference

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Risk of pancreatic adenocarcinoma in chronic pancreatitis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

27 July 2018

1 reference

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Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

27 July 2018

1 reference

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Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis

27 July 2018

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Notch signalling controls pancreatic cell differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Tumor-suppressive pathways in pancreatic carcinoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic adenocarcinomas frequently show p53 gene mutations.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

The role of c-myc in cell growth

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

The biology of SPARC, a protein that modulates cell-matrix interactions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic carcinomas of acinar and mixed acinar/ductal phenotypes in Ela-1-myc transgenic mice do not contain c-K-ras mutations.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Pancreatic tumor pathogenesis reflects the causative genetic lesion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Expression of c-erbB-2 in Human Pancreatic Adenocarcinomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Precursors to pancreatic cancer

27 July 2018

1 reference

High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients.

21 January 2018

1 reference

Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis

21 January 2018

1 reference

Mechanisms of pancreatic fibrosis.

21 January 2018

1 reference

Role of pancreatic stellate cells in pancreatic cancer metastasis.

21 January 2018

1 reference

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

21 January 2018

1 reference

Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

21 January 2018

1 reference

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

21 January 2018

1 reference

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

Sonic hedgehog promotes desmoplasia in pancreatic cancer

21 January 2018

1 reference

Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway

21 January 2018

1 reference

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

21 January 2018

1 reference

Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis

21 January 2018

1 reference

Transcriptional regulation and transformation by Myc proteins

21 January 2018

1 reference

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

21 January 2018

1 reference

Emerging molecular biology of pancreatic cancer

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review)

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Molecular classification of human carcinomas by use of gene expression signatures.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Progression model for pancreatic cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253704

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

25 September 2018

1 reference

12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

1 reference

12 December 2020

Homozygous deletion map at 18q21.1 in pancreatic cancer

1 reference

12 December 2020

Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells

1 reference

12 December 2020

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression

1 reference

12 December 2020

Overexpression of p53 protein in adenocarcinoma of the pancreas

1 reference

12 December 2020

Ki-ras oncogene activation in preinvasive pancreatic cancer

1 reference

12 December 2020

NF-kappaB/Rel activation in cerulein pancreatitis

1 reference

12 December 2020

Immunohistochemical evaluation of HER-2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms

1 reference

12 December 2020

Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

1 reference

12 December 2020

The pancreatic duct and its arteriovenous relationship: an underutilized aid in the diagnosis and distinction of pancreatic adenocarcinoma from pancreatic intraepithelial neoplasia. A study of 126 pancreatectomy specimens

1 reference

12 December 2020

An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreas

1 reference

12 December 2020

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes

1 reference

12 December 2020

Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation

1 reference

12 December 2020

Isolation of quiescent human pancreatic stellate cells: a promising in vitro tool for studies of human pancreatic stellate cell biology

1 reference

12 December 2020

Molecular pathogenesis of pancreatic cancer

1 reference

12 December 2020

Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model

1 reference

12 December 2020

Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis

1 reference

12 December 2020

Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma

1 reference

12 December 2020

c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance

1 reference

12 December 2020

Systemic and local immunosuppression in pancreatic cancer patients

1 reference

12 December 2020

Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression

1 reference

12 December 2020

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

1 reference

12 December 2020

Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer

1 reference

12 December 2020

Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1002/MC.20827

1 reference

9 August 2017

1 reference

9 August 2017

1 reference