(Q35662225)

9 August 2017

title

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. (English)

1 reference

9 August 2017

Peter J Brown

20

0 references

Cheryl Arrowsmith

object named as

Cheryl H Arrowsmith

19

0 references

Dalia Barsyte-Lovejoy

23

object named as

Dalia Barsyte-Lovejoy

1 reference

9 August 2017

Hannah Nguyen

1

1 reference

9 August 2017

Abdellah Allali-Hassani

2

1 reference

9 August 2017

Stephen Antonysamy

3

1 reference

9 August 2017

Shawn Chang

4

1 reference

9 August 2017

Lisa Hong Chen

5

1 reference

9 August 2017

Carmen Curtis

6

1 reference

9 August 2017

Spencer Emtage

7

1 reference

9 August 2017

Li Fan

8

1 reference

9 August 2017

Tarun Gheyi

9

1 reference

9 August 2017

Fengling Li

10

1 reference

9 August 2017

Shichong Liu

11

1 reference

9 August 2017

Joseph R Martin

12

1 reference

9 August 2017

David Mendel

13

1 reference

9 August 2017

Jonathan B Olsen

14

1 reference

9 August 2017

Laura Pelletier

15

1 reference

9 August 2017

Tatiana Shatseva

16

1 reference

9 August 2017

Song Wu

17

1 reference

9 August 2017

Feiyu Fred Zhang

18

1 reference

9 August 2017

Robert M Campbell

21

1 reference

9 August 2017

Benjamin A Garcia

22

1 reference

9 August 2017

Mary Mader

24

1 reference

9 August 2017

Masoud Vedadi

25

1 reference

9 August 2017

language of work or name

English

0 references

publication date

30 March 2015

1 reference

Journal of Biological Chemistry

9 August 2017

published in

1 reference

9 August 2017

volume

290

1 reference

9 August 2017

issue

22

1 reference

9 August 2017

page(s)

13641-13653

1 reference

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Cancer epigenetics drug discovery and development: the challenge of hitting the mark

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Chromatin proteins and modifications as drug targets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Epigenetic protein families: a new frontier for drug discovery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Structural basis of substrate methylation and inhibition of SMYD2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Crystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal Domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Methylation of the retinoblastoma tumor suppressor by SMYD2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Cardiac deletion of Smyd2 is dispensable for mouse heart development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Repression of p53 activity by Smyd2-mediated methylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

The CCP4 suite: programs for protein crystallography

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447944

Small changes in expression affect predisposition to tumorigenesis

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.626861

Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25825497

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.626861

1 reference

9 August 2017

1 reference

9 August 2017

1 reference