(Q34038652)

30 July 2017

title

Chromatin proteins and modifications as drug targets (English)

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30 July 2017

1

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30 July 2017

Dashyant Dhanak

2

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30 July 2017

language of work or name

English

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publication date

1 October 2013

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30 July 2017

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30 July 2017

volume

502

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30 July 2017

issue

7472

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30 July 2017

page(s)

480-488

1 reference

https://scigraph.springernature.com/pub.10.1038/nature12751

30 July 2017

exact match

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cites work

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Targeting DNA methylation

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Targeting DNA methylation for epigenetic therapy

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Cancer genetics and epigenetics: two sides of the same coin?

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p53 is regulated by the lysine demethylase LSD1

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Minireview: role of protein methylation and demethylation in nuclear hormone signaling.

21 January 2018

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Histone modifying enzymes and cancer: going beyond histones.

21 January 2018

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Novel mutations target distinct subgroups of medulloblastoma.

21 January 2018

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The role of mutations in epigenetic regulators in myeloid malignancies

21 January 2018

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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 January 2018

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

21 January 2018

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New insights to the MLL recombinome of acute leukemias

21 January 2018

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hDOT1L links histone methylation to leukemogenesis

21 January 2018

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Polycomb group protein-mediated repression of transcription

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Analysis of the coding genome of diffuse large B-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Molecular mechanisms and potential functions of histone demethylases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

LSD1 inhibition: a therapeutic strategy in cancer?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE12751

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Demystified molecular pathology of NUT midline carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

21 January 2018

1 reference

12 December 2020

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

1 reference

12 December 2020

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

1 reference

12 December 2020

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines

1 reference

12 December 2020

Molecular biology. Genetic events that shape the cancer epigenome

1 reference

12 December 2020

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

1 reference

12 December 2020

Molecular mechanisms and potential functions of histone demethylases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12751

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE12751

1 reference

release_yv6xod424nhhtdpwuwgvkkoiwq

30 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yv6xod424nhhtdpwuwgvkkoiwq

24 November 2022

mapped directly with Wikidata item

1 reference