(Q36657774)

15 August 2017

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor (English)

1 reference

15 August 2017

Oleg Fedorov

5

0 references

Peter J. Brown

Peter J Brown

12

0 references

Stefan Knapp

Stefan Knapp

9

0 references

Cheryl Arrowsmith

Cheryl H Arrowsmith

10

0 references

David Smil

David Smil

2

0 references

Wolfram Tempel

4

Wolfram Tempel

1 reference

15 August 2017

Wenyu Yu

1

1 reference

15 August 2017

Fengling Li

3

1 reference

15 August 2017

Kong T Nguyen

6

1 reference

15 August 2017

Yuri Bolshan

7

1 reference

15 August 2017

Rima Al-Awar

8

1 reference

15 August 2017

Masoud Vedadi

11

1 reference

15 August 2017

Matthieu Schapira

13

1 reference

15 August 2017

language of work or name

English

0 references

publication date

30 January 2013

1 reference

Bioorganic & Medicinal Chemistry

15 August 2017

1 reference

15 August 2017

21

1 reference

15 August 2017

7

1 reference

15 August 2017

1787-1794

1 reference

Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L

15 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Lysine methylation of VCP by a member of a novel human protein methyltransferase family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

An allosteric inhibitor of protein arginine methyltransferase 3

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

The pathogenesis of mixed-lineage leukemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Fluorescence-based methods for screening writers and readers of histone methyl marks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Structural Chemistry of Human SET Domain Protein Methyltransferases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Chemogenetic analysis of human protein methyltransferases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

REFMAC5 for the refinement of macromolecular crystal structures

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Structural chemistry of the histone methyltransferases cofactor binding site.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Features and development of Coot

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

MolProbity: all-atom structure validation for macromolecular crystallography

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Structure and functional characterization of the atypical human kinase haspin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Molecular-recognition characteristics of SAM-binding riboswitches.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780262

Processing of X-ray diffraction data collected in oscillation mode

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23433670

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMC.2013.01.049

1 reference

15 August 2017

1 reference

15 August 2017

PubMed publication ID

23433670

1 reference