(Q29616621)

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28 January 2020

title

Epigenetic protein families: a new frontier for drug discovery (English)

2 references

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30 April 2017

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28 January 2020

1 reference

1

1 reference

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28 January 2020

author name string

Chas Bountra

2

1 reference

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28 January 2020

Paul V Fish

3

1 reference

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28 January 2020

Kevin Lee

4

1 reference

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28 January 2020

Matthieu Schapira

5

1 reference

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28 January 2020

language of work or name

1 reference

30 April 2017

publication date

13 April 2012

2 references

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30 April 2017

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Nature Reviews Drug Discovery

28 January 2020

published in

2 references

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30 April 2017

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28 January 2020

volume

11

2 references

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30 April 2017

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28 January 2020

issue

5

2 references

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30 April 2017

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28 January 2020

page(s)

384-400

2 references

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30 April 2017

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Epigenetics and the biological definition of gene x environment interactions

28 January 2020

cites work

1 reference

Epigenetic modifications as therapeutic targets

31 March 2020

1 reference

Epigenetic regulation of the neural transcriptome: the meaning of the marks.

31 March 2020

1 reference

Epigenetic modifications and human disease

31 March 2020

1 reference

The language of covalent histone modifications

31 March 2020

1 reference

Cellular memory and the histone code

31 March 2020

1 reference

Signaling network model of chromatin

31 March 2020

1 reference

Mapping and analysis of chromatin state dynamics in nine human cell types

31 March 2020

1 reference

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

31 March 2020

1 reference

Functions of site-specific histone acetylation and deacetylation

31 March 2020

1 reference

CBP/p300-mediated acetylation of histone H3 on lysine 56

31 March 2020

1 reference

Histone recognition and large-scale structural analysis of the human bromodomain family

31 March 2020

1 reference

The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

31 March 2020

1 reference

Histone demethylation by a family of JmjC domain-containing proteins

31 March 2020

1 reference

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

31 March 2020

1 reference

L3MBTL1, a histone-methylation-dependent chromatin lock

31 March 2020

1 reference

Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins

31 March 2020

1 reference

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

31 March 2020

1 reference

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

31 March 2020

1 reference

Regulation of chromatin by histone modifications

31 March 2020

1 reference

Chromatin modifications and their function

31 March 2020

1 reference

Histone arginine methylation

31 March 2020

1 reference

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

31 March 2020

1 reference

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

31 March 2020

1 reference

The epigenomics of cancer

31 March 2020

1 reference

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

31 March 2020

1 reference

Histone deacetylase 8 in neuroblastoma tumorigenesis

31 March 2020

1 reference

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

31 March 2020

1 reference

Roles of the EZH2 histone methyltransferase in cancer epigenetics

31 March 2020

1 reference

hDOT1L links histone methylation to leukemogenesis

31 March 2020

1 reference

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

31 March 2020

1 reference

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

31 March 2020

1 reference

Selective inhibition of BET bromodomains

31 March 2020

1 reference

Transcription factors as targets for cancer therapy

31 March 2020

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

Reflecting on 25 years with MYC.

31 March 2020

1 reference

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

31 March 2020

1 reference

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

31 March 2020

1 reference

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

31 March 2020

1 reference

ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.

31 March 2020

1 reference

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

31 March 2020

1 reference

PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function

31 March 2020

1 reference

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

31 March 2020

1 reference

Characterization of a recurrent translocation t(2;3)(p15-22;q26) occurring in acute myeloid leukaemia.

31 March 2020

1 reference

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

31 March 2020

1 reference

The genetic landscape of the childhood cancer medulloblastoma

31 March 2020

1 reference

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

31 March 2020

1 reference

The epigenetic basis of the Warburg effect.

31 March 2020

1 reference

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

31 March 2020

1 reference

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

1 reference

Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems

31 March 2020

1 reference

CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.

31 March 2020

1 reference

CREB binding protein is required for both short-term and long-term memory formation

31 March 2020

1 reference

Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex

31 March 2020

1 reference

Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype

31 March 2020

1 reference

Genetic and epigenetic defects in mental retardation.

31 March 2020

1 reference

31 March 2020

XLMR genes: update 2007.

1 reference

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

31 March 2020

1 reference

Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems

31 March 2020

1 reference

Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis.

31 March 2020

1 reference

SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy

31 March 2020

1 reference

Antidepressant actions of histone deacetylase inhibitors

31 March 2020

1 reference

SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution

31 March 2020

1 reference

Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder

31 March 2020

1 reference

Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

31 March 2020

1 reference

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

31 March 2020

1 reference

Histone deacetylases as regulators of inflammation and immunity

31 March 2020

1 reference

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.

31 March 2020

1 reference

Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells

31 March 2020

1 reference

Sirtuins and inflammation: Friends or foes?

31 March 2020

1 reference

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

31 March 2020

1 reference

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

31 March 2020

1 reference

Suppression of inflammation by a synthetic histone mimic

31 March 2020

1 reference

The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance

31 March 2020

1 reference

A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation

31 March 2020

1 reference

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

31 March 2020

1 reference

Epigenetic regulation of the alternatively activated macrophage phenotype

31 March 2020

1 reference

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

31 March 2020

1 reference

Fine tuning our cellular factories: sirtuins in mitochondrial biology

31 March 2020

1 reference

SIRT1 genetic variation is related to BMI and risk of obesity

31 March 2020

1 reference

TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.

31 March 2020

1 reference

Protective role of SIRT1 in diabetic vascular dysfunction

31 March 2020

1 reference

Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

31 March 2020

1 reference

Central administration of resveratrol improves diet-induced diabetes.

31 March 2020

1 reference

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

31 March 2020

1 reference

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

31 March 2020

1 reference

Glycemic memory associated epigenetic changes

31 March 2020

1 reference

Epigenetic modifications in pluripotent and differentiated cells

31 March 2020

1 reference

Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells

31 March 2020

1 reference

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells

31 March 2020

1 reference

Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.

31 March 2020

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

1 reference

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

31 March 2020

1 reference

A combined chemical and genetic approach for the generation of induced pluripotent stem cells

31 March 2020

1 reference

Histone deacetylases (HDACs): characterization of the classical HDAC family

31 March 2020

1 reference

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

31 March 2020

1 reference

Sirtuin chemical mechanisms

31 March 2020

1 reference

The biochemistry of sirtuins.

31 March 2020

1 reference

Lysine acetylation targets protein complexes and co-regulates major cellular functions

31 March 2020

1 reference

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

31 March 2020

1 reference

HDAC6 is a microtubule-associated deacetylase

31 March 2020

1 reference

Clinical studies of histone deacetylase inhibitors.

31 March 2020

1 reference

31 March 2020

1 reference

The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

31 March 2020

1 reference

Structural biology of human metal-dependent histone deacetylases

31 March 2020

1 reference

Chemical phylogenetics of histone deacetylases

31 March 2020

1 reference

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

31 March 2020

1 reference

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

31 March 2020

1 reference

Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis

31 March 2020

1 reference

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

31 March 2020

1 reference

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

31 March 2020

1 reference

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

31 March 2020

1 reference

p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals

31 March 2020

1 reference

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

31 March 2020

1 reference

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

31 March 2020

1 reference

Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells

31 March 2020

1 reference

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

1 reference

Mammalian sirtuins: biological insights and disease relevance

31 March 2020

1 reference

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

31 March 2020

1 reference

Sirtuin 1 (SIRT1): the misunderstood HDAC.

31 March 2020

1 reference

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

31 March 2020

1 reference

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

31 March 2020

1 reference

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

31 March 2020

1 reference

Chemical biology of histone acetyltransferase natural compounds modulators

31 March 2020

1 reference

Histone acetyl transferases as emerging drug targets.

31 March 2020

1 reference

Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF

31 March 2020

1 reference

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

31 March 2020

1 reference

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

31 March 2020

1 reference

Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines

31 March 2020

1 reference

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

31 March 2020

1 reference

Protein methyltransferases as a target class for drug discovery

31 March 2020

1 reference

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

31 March 2020

1 reference

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

31 March 2020

1 reference

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

31 March 2020

1 reference

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

31 March 2020

1 reference

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

31 March 2020

1 reference

Structural basis of substrate methylation and inhibition of SMYD2

31 March 2020

1 reference

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

31 March 2020

1 reference

Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases

31 March 2020

1 reference

Structural chemistry of the histone methyltransferases cofactor binding site.

31 March 2020

1 reference

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors

31 March 2020

1 reference

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases.

31 March 2020

1 reference

Small molecule regulators of protein arginine methyltransferases

31 March 2020

1 reference

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors

31 March 2020

1 reference

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

31 March 2020

1 reference

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

31 March 2020

1 reference

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

31 March 2020

1 reference

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor

31 March 2020

1 reference

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

31 March 2020

1 reference

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

31 March 2020

1 reference

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

31 March 2020

1 reference

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

31 March 2020

1 reference

Multivalent engagement of chromatin modifications by linked binding modules

31 March 2020

1 reference

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

31 March 2020

1 reference

Structure and function of a human TAFII250 double bromodomain module

31 March 2020

1 reference

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association

31 March 2020

1 reference

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

31 March 2020

1 reference

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

31 March 2020

1 reference

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

31 March 2020

1 reference

Epigenetic opportunities and challenges in cancer

31 March 2020

1 reference

Epigenetic therapies for non-oncology indications

31 March 2020

1 reference

Epigenetic transgenerational actions of endocrine disruptors and male fertility

31 March 2020

1 reference

Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease

31 March 2020

1 reference

Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function

31 March 2020

1 reference

Epigenetics: Unravelling the cancer code

31 March 2020

1 reference

Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway

31 March 2020

1 reference

Chemogenetic analysis of human protein methyltransferases

31 March 2020

1 reference

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

31 March 2020

1 reference

Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

31 March 2020

1 reference

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

31 March 2020

1 reference

Romidepsin: a novel histone deacetylase inhibitor for cancer

31 March 2020

1 reference

Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation

31 March 2020

1 reference

Identification of novel isoform-selective inhibitors within class I histone deacetylases

31 March 2020

1 reference

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

31 March 2020

1 reference

Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial

31 March 2020

1 reference

The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells

31 March 2020

1 reference

Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).

31 March 2020

1 reference

Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile

31 March 2020

1 reference

SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.

31 March 2020

1 reference

CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activity

31 March 2020

1 reference

PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells

31 March 2020

1 reference

The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo

31 March 2020

1 reference

A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL.

31 March 2020

1 reference

Abnormal histone modification patterns in lupus CD4+ T cells

31 March 2020

1 reference

12 December 2020

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo

1 reference

12 December 2020

DNA methylation and cancer

1 reference

12 December 2020

SMART, a simple modular architecture research tool: identification of signaling domains

1 reference

12 December 2020

Histone acetylation and an epigenetic code

1 reference

12 December 2020

HDAC Inhibitors--CHI's Third Annual Conference.

1 reference

12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22498752

Identifiers

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

59726

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Dimensions Publication ID

28 January 2020

1007920084

0 references

59726

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22498752

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

59726

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22498752%20AND%20SRC:MED&resulttype=core&format=json