(Q35666588)

9 August 2017

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title

From pharmacokinetics to pharmacogenomics: a new approach to tailor immunosuppressive therapy (English)

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9 August 2017

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Giuseppe Remuzzi

3

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Dario Cattaneo

series ordinal

1

object named as

Dario Cattaneo

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9 August 2017

2

Norberto Perico

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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American Journal of Transplantation

9 August 2017

published in

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9 August 2017

volume

4

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9 August 2017

issue

3

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9 August 2017

page(s)

299-310

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Relevance of pharmacokinetics in narrow therapeutic index drugs

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Genetics of drug response to immunosuppressive treatment and prospects for personalized therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Immunosuppressant drugs--the role of therapeutic drug monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

A randomized double-blind, multicenter plasma concentration controlled study of the safety and efficacy of oral mycophenolate mofetil for the prevention of acute rejection after kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Insights into pharmacogenomics and its impact upon immunosuppressive therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

The Pennsylvania State University College of Medicine 1990 Bernard B. Brodie Lecture. Pharmacogenetics: past and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Pharmacogenetics and adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

High-diversity combinatorial libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

The use of single-nucleotide polymorphism maps in pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Therapeutic drug monitoring of immunosuppressive drugs in kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Use of the clonal assay for the measurement of frequencies of HPRT mutants in T-lymphocytes from five control populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Pharmacokinetics help optimizing mycophenolate mofetil dosing in kidney transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Polymorphisms in UDP glucuronosyltransferase genes: functional consequences and clinical relevance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

A mutational analysis of the active site of human type II inosine 5'-monophosphate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Pharmacogenomics--drug disposition, drug targets, and side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Frequency of cytochrome P450 3A4 variant genotype in transplant population and lack of association with cyclosporin clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Association of the CYP3A4*1B 5'-flanking region polymorphism with cyclosporine pharmacokinetics in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Identification of functionally variant MDR1 alleles among European Americans and African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

The structure of haplotype blocks in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Association of initial response to prednisone treatment in childhood acute lymphoblastic leukaemia and polymorphisms within the tumour necrosis factor and the interleukin-10 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

The 14-3-3 proteins positively regulate rapamycin-sensitive signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

Mechanisms of resistance to rapamycins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-6143.2004.00312.X

10.1111/J.1600-6143.2004.00312.X

21 January 2018

Identifiers

DOI

1 reference

9 August 2017

1 reference