(Q35669113)

9 August 2017

Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion (English)

1 reference

9 August 2017

1 reference

3

Emil R Unanue

1 reference

9 August 2017

James F Mohan

1

1 reference

PubMed ID

22065673

9 August 2017

Shirley J Petzold

series ordinal

2

1 reference

PubMed ID

22065673

9 August 2017

language of work or name

English

0 references

publication date

7 November 2011

1 reference

Journal of Experimental Medicine

9 August 2017

1 reference

9 August 2017

208

1 reference

9 August 2017

12

1 reference

9 August 2017

2375-2383

1 reference

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Autoimmune T cell responses in the central nervous system

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Conformational isomers of a peptide-class II major histocompatibility complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Post-translational modifications of self antigens: implications for autoimmunity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Peptide register shifting within the MHC groove: theory becomes reality

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Production of soluble MHC class II proteins with covalently bound single peptides

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Analysis of the spontaneous T cell response to insulin in NOD mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Influence of a dominant cryptic epitope on autoimmune T cell tolerance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3256971

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

25 September 2018

1 reference

12 December 2020

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

12 December 2020

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

1 reference

12 December 2020

Quantitative analysis of the T cell repertoire that escapes negative selection

1 reference

12 December 2020

Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers

1 reference

12 December 2020

DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope

1 reference

12 December 2020

Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20111502

1 reference

9 August 2017

1 reference

9 August 2017

1 reference

PubMed ID

22065673