(Q35669207)

9 August 2017

title

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site (English)

1 reference

9 August 2017

6

Fuyuhiko Inagaki

1 reference

9 August 2017

7

Lewis E Kay

1 reference

9 August 2017

Mohammad T Mazhab-Jafari

Mohammad T Mazhab-Jafari

1

0 references

Matthew J. Smith

Matthew J Smith

3

0 references

Christopher B Marshall

Christopher B Marshall

2

0 references

Mitsuhiko Ikura

Mitsuhiko Ikura

9

0 references

author name string

Geneviève M C Gasmi-Seabrook

4

1 reference

9 August 2017

Peter B Stathopulos

5

1 reference

9 August 2017

Benjamin G Neel

8

1 reference

9 August 2017

language of work or name

English

0 references

publication date

4 May 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

1 reference

9 August 2017

volume

112

1 reference

9 August 2017

issue

21

1 reference

9 August 2017

page(s)

6625-6630

1 reference

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic Domain

12 July 2018

1 reference

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Dragging ras back in the ring

12 July 2018

1 reference

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The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology

12 July 2018

1 reference

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Advances in NMR structures of integral membrane proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Regulating the regulator: post-translational modification of RAS

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

RAS oncogenes: weaving a tumorigenic web

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Frequent pathway mutations of splicing machinery in myelodysplasia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Protein NMR using paramagnetic ions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Ras membrane orientation and nanodomain localization generate isoform diversity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

PBEQ-Solver for online visualization of electrostatic potential of biomolecules

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Electrostatic interactions positively regulate K-Ras nanocluster formation and function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

A novel switch region regulates H-ras membrane orientation and signal output

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

HADDOCK versus HADDOCK: new features and performance of HADDOCK2.0 on the CAPRI targets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Germline KRAS mutations cause Noonan syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Pound-wise but penny-foolish: How well do micromolecules fare in macromolecular refinement?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Biochemical and functional characterization of germ line KRAS mutations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

BRAF and KRAS mutations in stomach cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4450377

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1419895112

Rotational and Translational Dynamics of Ras Proteins upon Binding to Model Membrane Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1419895112

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1419895112

Influence of Cholesterol and Water Content on Phospholipid Lateral Diffusion in Bilayers†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1419895112

CHARMM-GUI: a web-based graphical user interface for CHARMM

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25941399

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1419895112

1 reference

9 August 2017

0 references

1 reference

9 August 2017

1 reference