(Q35688942)

English

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

scientific article published on 7 April 2015

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage (English)

1 reference

Europe PubMed Central

9 August 2017

0 references

Alzheimer's disease

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author name string

Yohei Shibuya

1

1 reference

Europe PubMed Central

9 August 2017

Zhaoyang Niu

2

1 reference

Europe PubMed Central

9 August 2017

Elena Y Bryleva

3

1 reference

Europe PubMed Central

9 August 2017

Brent T Harris

4

1 reference

Europe PubMed Central

9 August 2017

Stephanie R Murphy

5

1 reference

Europe PubMed Central

9 August 2017

Alireza Kheirollah

6

1 reference

Europe PubMed Central

9 August 2017

Zachary D Bowen

7

1 reference

Europe PubMed Central

9 August 2017

Catherine C Y Chang

8

1 reference

Europe PubMed Central

9 August 2017

Ta-Yuan Chang

9

1 reference

Europe PubMed Central

9 August 2017

publication date

7 April 2015

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Europe PubMed Central

9 August 2017

Neurobiology of Aging

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Europe PubMed Central

9 August 2017

36

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Europe PubMed Central

9 August 2017

7

1 reference

Europe PubMed Central

9 August 2017

2248-2259

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Europe PubMed Central

9 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4457653/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

1 reference

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1 reference

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Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

1 reference

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Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.

1 reference

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1 reference

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1 reference

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1 reference

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Methods in mammalian autophagy research

1 reference

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Cholesterol depletion induces autophagy

1 reference

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1 reference

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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1 reference

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1 reference

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1 reference

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Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

25 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

25 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

25 September 2018

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

25 September 2018

Acyl-coenzyme A:cholesterol acyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

25 September 2018

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4457653

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Isolation and culture of adult rat hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25930235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25930235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of the tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25930235

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NEUROBIOLAGING.2015.04.002

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

ResearchGate publication ID

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