(Q37824813)

23 August 2017

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title

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease (English)

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23 August 2017

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23 August 2017

2

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language of work or name

English

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publication date

31 December 2010

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Nature Reviews Neuroscience

23 August 2017

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23 August 2017

12

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23 August 2017

65-72

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23 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrn2967

23 August 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons.

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Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal.

31 March 2020

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

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Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

31 March 2020

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31 March 2020

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Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.

31 March 2020

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Tau suppression in a neurodegenerative mouse model improves memory function

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Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease

31 March 2020

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Interaction of tau protein with the dynactin complex

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Microtubules in Dendritic Spine Development and Plasticity

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31 March 2020

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31 March 2020

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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

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31 March 2020

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31 March 2020

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

31 March 2020

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Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

31 March 2020

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Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau

31 March 2020

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31 March 2020

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

31 March 2020

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

31 March 2020

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Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

31 March 2020

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31 March 2020

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12 December 2020

Tau interacts with src-family non-receptor tyrosine kinases

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12 December 2020

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease

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12 December 2020

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

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12 December 2020

Identifiers

DOI

10.1038/NRN2967

1 reference

23 August 2017

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PubMed ID

21193853