(Q35698954)

9 August 2017

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice (English)

1 reference

9 August 2017

14

Kylie L Gorringe

1 reference

9 August 2017

Karen E Sheppard

11

0 references

Theo Mantamadiotis

Theo Mantamadiotis

10

0 references

Carleen Cullinane

Carleen Cullinane

16

0 references

Wayne A. Phillips

Wayne A Phillips

21

0 references

Ricky W Johnstone

Ricky W Johnstone

19

0 references

Grant McArthur

Grant A McArthur

20

0 references

Ian G. Campbell

Ian G Campbell

13

0 references

Rodney J. Hicks

Rodney J Hicks

17

0 references

Georgina L Ryland

12

Georgina L Ryland

1 reference

9 August 2017

Kathryn M Kinross

1

1 reference

9 August 2017

Karen G Montgomery

2

1 reference

9 August 2017

Margarete Kleinschmidt

3

1 reference

9 August 2017

Paul Waring

4

1 reference

9 August 2017

Ivan Ivetac

5

1 reference

9 August 2017

Anjali Tikoo

6

1 reference

9 August 2017

Mirette Saad

7

1 reference

9 August 2017

Lauren Hare

8

1 reference

9 August 2017

Vincent Roh

9

1 reference

9 August 2017

James G Christensen

15

1 reference

9 August 2017

Richard B Pearson

18

1 reference

9 August 2017

language of work or name

English

0 references

publication date

3 January 2012

1 reference

Journal of Clinical Investigation

9 August 2017

1 reference

9 August 2017

122

1 reference

9 August 2017

553-557

1 reference

9 August 2017

2

1 reference

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

9 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Integrated genomic analyses of ovarian carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

PI(3)king apart PTEN's role in cancer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

The biology of ovarian cancer: new opportunities for translation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Large-scale genomic analysis of ovarian carcinomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

PI3K pathway alterations in cancer: variations on a theme

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Class I PI3K in oncogenic cellular transformation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

High frequency of mutations of the PIK3CA gene in human cancers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

PIK3CA is implicated as an oncogene in ovarian cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266789

Mutation of the PIK3CA gene in ovarian and breast cancer

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22214849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PTEN expression in clear cell adenocarcinoma of the ovary

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22214849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI59309

1 reference

release_kibxj2qxgrgnhp223odxzljog4

9 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kibxj2qxgrgnhp223odxzljog4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3266789

1 reference

9 August 2017

1 reference