(Q35747799)

10 August 2017

title

Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump (English)

1 reference

10 August 2017

1 reference

Dongfang Yang

1

1 reference

10 August 2017

Jian Yang

2

1 reference

10 August 2017

Deshi Shi

3

1 reference

10 August 2017

Da Xiao

4

1 reference

10 August 2017

Yi-Tzai Chen

5

1 reference

10 August 2017

Chris Black

6

1 reference

10 August 2017

Ruitang Deng

7

1 reference

10 August 2017

Bingfang Yan

8

1 reference

10 August 2017

publication date

14 January 2012

1 reference

Journal of Lipid Research

10 August 2017

published in

1 reference

10 August 2017

volume

53

1 reference

10 August 2017

issue

3

1 reference

10 August 2017

page(s)

529-539

1 reference

Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor

10 August 2017

cites work

1 reference

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Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication

27 July 2018

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Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure

27 July 2018

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27 July 2018

Bile acid transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

27 July 2018

1 reference

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Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice

27 July 2018

1 reference

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The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Cardiorenal consequences of atherosclerosis and statins therapy: from the past to the future

27 July 2018

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CYP3A4 polymorphisms - potential risk factors for breast and prostate cancer: a huge review

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Guggulipid for the treatment of hypercholesterolemia: a randomized controlled trial

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion

27 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Bile acids: regulation of synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

GUGULIPID: a natural cholesterol-lowering agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

A natural product that lowers cholesterol as an antagonist ligand for FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Surge in expression of carboxylesterase 1 during the post-neonatal stage enables a rapid gain of the capacity to activate the anti-influenza prodrug oseltamivir

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Regulation of rat carboxylesterase expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): a dose-dependent decrease in mRNA levels but a biphasic change in protein levels and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M014688

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276476

Clinical trials with gugulipid. A new hypolipidaemic agent

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22246918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22246918

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M014688

1 reference

10 August 2017

1 reference

10 August 2017

1 reference