(Q35762470)

10 August 2017

A means to a DNA end: the many roles of Ku. (English)

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10 August 2017

Jessica A Downs

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Stephen P Jackson

object named as

Stephen P Jackson

series ordinal

2

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publication date

1 May 2004

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Nature Reviews Molecular Cell Biology

10 August 2017

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10 August 2017

5

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10 August 2017

367-378

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10 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrm1367

10 August 2017

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cites work

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap

1 reference

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

31 March 2020

1 reference

Dimerization and nuclear localization of ku proteins

31 March 2020

1 reference

DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p.

31 March 2020

1 reference

Dimerization, translocation and localization of Ku70 and Ku80 proteins

31 March 2020

1 reference

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

31 March 2020

1 reference

Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb

31 March 2020

1 reference

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

31 March 2020

1 reference

Molecular and biochemical characterization of xrs mutants defective in Ku80.

31 March 2020

1 reference

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

31 March 2020

1 reference

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

31 March 2020

1 reference

Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

31 March 2020

1 reference

Deletion of Ku86 causes early onset of senescence in mice

31 March 2020

1 reference

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

31 March 2020

1 reference

Analysis of the mechanism of interaction of simian Ku protein with DNA

31 March 2020

1 reference

Production and characterization of recombinant human Ku antigen

31 March 2020

1 reference

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

31 March 2020

1 reference

Direct transfer of Ku between DNA molecules with nonhomologous ends.

31 March 2020

1 reference

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

31 March 2020

1 reference

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

31 March 2020

1 reference

Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system

31 March 2020

1 reference

SAP - a putative DNA-binding motif involved in chromosomal organization

31 March 2020

1 reference

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

31 March 2020

1 reference

31 March 2020

1 reference

The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

31 March 2020

1 reference

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

31 March 2020

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Differential DNA Binding of Ku Antigen Determines Its Involvement in DNA Replication

31 March 2020

1 reference

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

31 March 2020

1 reference

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

31 March 2020

1 reference

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

31 March 2020

1 reference

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

31 March 2020

1 reference

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

31 March 2020

1 reference

KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity

31 March 2020

1 reference

Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

31 March 2020

1 reference

Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

31 March 2020

1 reference

Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair

31 March 2020

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Identification of bacterial homologues of the Ku DNA repair proteins

31 March 2020

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Mechanism and regulation of human non-homologous DNA end-joining

31 March 2020

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Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

31 March 2020

1 reference

DNA double strand break repair and chromosomal translocation: lessons from animal models

31 March 2020

1 reference

The DNA-dependent protein kinase

31 March 2020

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DNA end-joining catalyzed by human cell-free extracts

31 March 2020

1 reference

Nonhomologous DNA end joining in cell-free systems

31 March 2020

1 reference

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

31 March 2020

1 reference

Ku recruits the XRCC4-ligase IV complex to DNA ends

31 March 2020

1 reference

Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase

31 March 2020

1 reference

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

31 March 2020

1 reference

Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination

31 March 2020

1 reference

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae

31 March 2020

1 reference

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

31 March 2020

1 reference

Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo

31 March 2020

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Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis

31 March 2020

1 reference

The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage

31 March 2020

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Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes

31 March 2020

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Identification of a DNA nonhomologous end-joining complex in bacteria

31 March 2020

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Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

31 March 2020

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Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

31 March 2020

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Defining interactions between DNA-PK and ligase IV/XRCC4.

31 March 2020

1 reference

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

31 March 2020

1 reference

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

31 March 2020

1 reference

Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences

31 March 2020

1 reference

Binding of double-strand breaks in DNA by human Rad52 protein

31 March 2020

1 reference

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

31 March 2020

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DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

31 March 2020

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Rad52 and Ku bind to different DNA structures produced early in double-strand break repair

31 March 2020

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Transient association of Ku with nuclear substrates characterized using fluorescence photobleaching

31 March 2020

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DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D

31 March 2020

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Ku affects the ATM-dependent S phase checkpoint following ionizing radiation

31 March 2020

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Ku80 is required for immunoglobulin isotype switching

31 March 2020

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

31 March 2020

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Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

31 March 2020

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The mechanism and regulation of chromosomal V(D)J recombination

31 March 2020

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Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

31 March 2020

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DNA-PK is essential only for coding joint formation in V(D)J recombination

31 March 2020

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Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

31 March 2020

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

31 March 2020

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Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products

31 March 2020

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Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase

31 March 2020

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The role of DNA breaks in genomic instability and tumorigenesis

31 March 2020

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

31 March 2020

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Involvement of DNA end-binding protein Ku in Ty element retrotransposition

31 March 2020

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A role for DNA-PK in retroviral DNA integration

31 March 2020

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Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

31 March 2020

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The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku.

31 March 2020

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Localization of the gam gene of bacteriophage mu and characterisation of the gene product.

31 March 2020

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Purification of overexpressed gam gene protein from bacteriophage Mu by denaturation-renaturation techniques and a study of its DNA-binding properties

31 March 2020

1 reference

Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast

31 March 2020

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

31 March 2020

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

31 March 2020

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Yeast Ku as a regulator of chromosomal DNA end structure

31 March 2020

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The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae

31 March 2020

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Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku.

31 March 2020

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Ku complex controls the replication time of DNA in telomere regions.

31 March 2020

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The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini

31 March 2020

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Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

31 March 2020

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Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing

31 March 2020

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Protection of telomeres by the Ku protein in fission yeast

31 March 2020

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Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.

31 March 2020

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Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

31 March 2020

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Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast

31 March 2020

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Ku is associated with the telomere in mammals

31 March 2020

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Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

31 March 2020

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Human Ku70/80 associates physically with telomerase through interaction with hTERT

31 March 2020

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

31 March 2020

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DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

31 March 2020

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Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.

31 March 2020

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Distinct roles for Ku protein in transcriptional reinitiation and DNA repair

31 March 2020

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DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I

31 March 2020

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Mechanism and control of class-switch recombination

31 March 2020

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Immunity through DNA deamination

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1367

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10 August 2017

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PubMed ID

15122350