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Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.
scientific article published on 5 December 2011
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Europe PubMed Central
PMC publication ID
3281723
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
title
Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
author
Noel A Warfel
series ordinal
1
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Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
Alexandra C. Newton
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2
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Alexandra C Newton
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
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English
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publication date
5 December 2011
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Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
published in
Journal of Biological Chemistry
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
volume
287
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
page(s)
3610-3616
1 reference
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Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
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17 January 2020
cites work
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Integrative genomic profiling of human prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
The nuts and bolts of AGC protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Serine/threonine phosphatases: mechanism through structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
PHLiPPing the switch on Akt and protein kinase C signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
The phosphatase PHLPP controls the cellular levels of protein kinase C
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
X chromosomal abnormalities in basal-like human breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Reverse engineering of regulatory networks in human B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Mammalian Sterile20-like kinase 1 and the regulation of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Caspase and calpain substrates: roles in synaptic plasticity and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
2 October 2017
PHLPP-1 negatively regulates Akt activity and survival in the heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
12 July 2018
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
12 July 2018
Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
12 July 2018
Mechanism of activation and function of protein kinase B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
12 July 2018
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
25 September 2018
Novel genes associated with malignant melanoma but not benign melanocytic lesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
25 September 2018
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3281723
retrieved
25 September 2018
Identifiers
DOI
10.1074/JBC.R111.318675
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PMC publication ID
3281723
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
PubMed publication ID
22144674
1 reference
stated in
Europe PubMed Central
PMC publication ID
3281723
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22144674%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 January 2020
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