(Q35764318)

10 August 2017

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title

Genetic and pharmacological suppression of polyglutamine-dependent neuronal dysfunction in Caenorhabditis elegans (English)

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10 August 2017

Caenorhabditis elegans

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author name string

J Alex Parker

1

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10 August 2017

Sébastien Holbert

2

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10 August 2017

Emmanuel Lambert

3

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10 August 2017

Salima Abderrahmane

4

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10 August 2017

Christian Néri

5

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10 August 2017

1 January 2004

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Journal of Molecular Neuroscience

10 August 2017

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10 August 2017

23

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10 August 2017

61-68

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10 August 2017

1-2

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https://scigraph.springernature.com/pub.10.1385/jmn:23:1-2:061

10 August 2017

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cites work

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12 December 2020

Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain.

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12 December 2020

New light on polyglutamine neurodegenerative disorders: interference with transcription

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans.

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Lessons from animal models of Huntington's disease

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

Genetic suppression of polyglutamine toxicity in Drosophila

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12 December 2020

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

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From chemical to drug: neurodegeneration drug screening and the ethics of clinical trials

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12 December 2020

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

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12 December 2020

Interaction of Huntington disease protein with transcriptional activator Sp1

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12 December 2020

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

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12 December 2020

SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes

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12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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12 December 2020

Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons

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12 December 2020

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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12 December 2020

Polyglutamine pathogenesis.

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12 December 2020

The embryonic cell lineage of the nematode Caenorhabditis elegans

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The epidemiology of Huntington's disease

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12 December 2020

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

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12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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12 December 2020

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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12 December 2020

CREB-binding protein sequestration by expanded polyglutamine

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12 December 2020

The Structure of the Nervous System of the Nematode Caenorhabditis elegans

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12 December 2020

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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12 December 2020

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

1 reference

12 December 2020

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

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12 December 2020

PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains

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12 December 2020

Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain

1 reference

12 December 2020

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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12 December 2020

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

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12 December 2020

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

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12 December 2020

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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12 December 2020

Huntingtin interacts with a family of WW domain proteins

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12 December 2020

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

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12 December 2020

Huntingtin interacts with cystathionine beta-synthase

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12 December 2020

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

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12 December 2020

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

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12 December 2020

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

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12 December 2020

Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

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12 December 2020

Dying for a cause: invertebrate genetics takes on human neurodegeneration

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12 December 2020

Huntingtin: a single bait hooks many species

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12 December 2020

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

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12 December 2020

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

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12 December 2020

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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12 December 2020

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

1 reference

12 December 2020

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

12 December 2020

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

1 reference

12 December 2020

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

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12 December 2020

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

1 reference

12 December 2020

Recent advances on the pathogenesis of Huntington's disease

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12 December 2020

HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

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12 December 2020

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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12 December 2020

Identifiers

DOI

10.1385/JMN:23:1-2:061

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Dimensions Publication ID

10 August 2017

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