(Q35770168)

10 August 2017

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title

Inflammatory resolution: new opportunities for drug discovery (English)

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10 August 2017

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Derek W Gilroy

1

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Mauro Perretti

series ordinal

3

object named as

Mauro Perretti

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10 August 2017

Toby Lawrence

2

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PubMed ID

15136788

10 August 2017

Adriano G Rossi

series ordinal

4

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10 August 2017

1 May 2004

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Nature Reviews Drug Discovery

10 August 2017

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10 August 2017

3

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10 August 2017

401-416

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10 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd1383

10 August 2017

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Evidence for a posible endogenous antigen in chronic inflammation

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Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis: 2001 update. American College of Rheumatology Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis

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Glucocorticoid-regulated gene expression during cutaneous wound repair

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Selective cyclooxygenase-2 (COX-2) inhibitors and potential risk of cardiovascular events.

31 March 2020

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Prostaglandin D synthase: structure and function

31 March 2020

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Cyclopentenone prostaglandins: new insights on biological activities and cellular targets

31 March 2020

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PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

31 March 2020

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

31 March 2020

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Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?

31 March 2020

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15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.

31 March 2020

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Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2.

31 March 2020

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Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathw

31 March 2020

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Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression

31 March 2020

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Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

31 March 2020

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Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions

31 March 2020

1 reference

Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells

31 March 2020

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Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction

31 March 2020

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Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators

31 March 2020

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Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2.

31 March 2020

1 reference

Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction

31 March 2020

1 reference

Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

31 March 2020

1 reference

Inducible cyclooxygenase may have anti-inflammatory properties

31 March 2020

1 reference

A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation

31 March 2020

1 reference

Inducible cyclooxygenase-derived 15-deoxyΔ12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis

31 March 2020

1 reference

Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism

31 March 2020

1 reference

Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.

31 March 2020

1 reference

Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis

31 March 2020

1 reference

Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin

31 March 2020

1 reference

The cyclopentenone prostaglandin 15-deoxy-delta(12,14)- PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat.

31 March 2020

1 reference

The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.

31 March 2020

1 reference

15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

31 March 2020

1 reference

Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis

31 March 2020

1 reference

Prostaglandin D2 as a mediator of allergic asthma

31 March 2020

1 reference

Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine

31 March 2020

1 reference

Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2.

31 March 2020

1 reference

Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance

31 March 2020

1 reference

Heme oxygenase: a novel target for the modulation of the inflammatory response

31 March 2020

1 reference

Neutrophil activation by heme: implications for inflammatory processes.

31 March 2020

1 reference

Anti-Inflammatory Actions of the Heme Oxygenase-1 Pathway

31 March 2020

1 reference

Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants

31 March 2020

1 reference

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

31 March 2020

1 reference

Alleviation of graft-versus-host disease after conditioning with cobalt-protoporphyrin, an inducer of heme oxygenase-1

31 March 2020

1 reference

Lipid mediator class switching during acute inflammation: signals in resolution.

31 March 2020

1 reference

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction

31 March 2020

1 reference

Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor

31 March 2020

1 reference

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

31 March 2020

1 reference

Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia

31 March 2020

1 reference

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

31 March 2020

1 reference

Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo

31 March 2020

1 reference

International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors

31 March 2020

1 reference

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

31 March 2020

1 reference

Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing

31 March 2020

1 reference

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

31 March 2020

1 reference

Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

31 March 2020

1 reference

Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy

31 March 2020

1 reference

Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases

31 March 2020

1 reference

Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.

31 March 2020

1 reference

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).

31 March 2020

1 reference

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis.

31 March 2020

1 reference

15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure

31 March 2020

1 reference

An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile

31 March 2020

1 reference

Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis

31 March 2020

1 reference

Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence

31 March 2020

1 reference

Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation

31 March 2020

1 reference

Corpse clearance defines the meaning of cell death

31 March 2020

1 reference

From bench to clinic with apoptosis-based therapeutic agents

31 March 2020

1 reference

Apoptosis in disease: about shortage and excess

31 March 2020

1 reference

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

31 March 2020

1 reference

A blast from the past: clearance of apoptotic cells regulates immune responses.

31 March 2020

1 reference

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.

31 March 2020

1 reference

An appetite for apoptotic cells? Controversies and challenges

31 March 2020

1 reference

Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active Rac.

31 March 2020

1 reference

Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin

31 March 2020

1 reference

Resolution of lung inflammation by CD44

31 March 2020

1 reference

Eosinophil apoptosis and the resolution of airway inflammation in asthma

31 March 2020

1 reference

Therapeutic approaches to the modulation of apoptosis

31 March 2020

1 reference

31 March 2020

1 reference

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

31 March 2020

1 reference

Caspase inhibitors as anti-inflammatory and antiapoptotic agents.

31 March 2020

1 reference

The caspase inhibitor z-VAD is more effective than CD18 adhesion blockade in reducing muscle ischemia-reperfusion injury: implication for clinical trials

31 March 2020

1 reference

The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury

31 March 2020

1 reference

First clinical trial of a novel caspase inhibitor: anti-apoptotic caspase inhibitor, IDN-6556, improves liver enzymes.

31 March 2020

1 reference

New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?

31 March 2020

1 reference

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

31 March 2020

1 reference

The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes

31 March 2020

1 reference

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

31 March 2020

1 reference

Possible new role for NF-kappaB in the resolution of inflammation.

31 March 2020

1 reference

Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.

31 March 2020

1 reference

Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.

31 March 2020

1 reference

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

31 March 2020

1 reference

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

31 March 2020

1 reference

A comparison of the acute inflammatory response in adrenalectomised and sham-operated rats

31 March 2020

1 reference

The effect of adrenalectomy on interleukin-1 release in vitro and in vivo

31 March 2020

1 reference

Molecular mechanisms of glucocorticosteroid actions.

31 March 2020

1 reference

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

31 March 2020

1 reference

Bioenergetics of immune functions: fundamental and therapeutic aspects

31 March 2020

1 reference

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

31 March 2020

1 reference

Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids

31 March 2020

1 reference

Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line

31 March 2020

1 reference

Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids

31 March 2020

1 reference

Annexins: from structure to function

31 March 2020

1 reference

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

31 March 2020

1 reference

Formyl-peptide receptors revisited

31 March 2020

1 reference

Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1.

31 March 2020

1 reference

Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse

31 March 2020

1 reference

Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis.

31 March 2020

1 reference

The annexin 1 receptor(s): is the plot unravelling?

31 March 2020

1 reference

Adenosine: an endogenous regulator of innate immunity

31 March 2020

1 reference

Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

31 March 2020

1 reference

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

31 March 2020

1 reference

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

31 March 2020

1 reference

Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.

31 March 2020

1 reference

Adenosine: a potential mediator of immunosuppression in multiple organ failure

31 March 2020

1 reference

Too much of a good thing: adenosine overload in adenosine-deaminase-deficient mice

31 March 2020

1 reference

Targeting melanocortin receptors as a novel strategy to control inflammation.

31 March 2020

1 reference

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

31 March 2020

1 reference

Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

31 March 2020

1 reference

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation

31 March 2020

1 reference

Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions

31 March 2020

1 reference

Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils

31 March 2020

1 reference

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes

31 March 2020

1 reference

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

31 March 2020

1 reference

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

31 March 2020

1 reference

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

31 March 2020

1 reference

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

31 March 2020

1 reference

Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages

31 March 2020

1 reference

15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit

31 March 2020

1 reference

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma

31 March 2020

1 reference

Aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs inhibit neutrophil-mediated changes in vascular permeability.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1383

1 reference

10 August 2017

1 reference

PubMed ID

15136788